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小儿轮状病毒肠炎致全身炎症反应综合征IL-2、IL-6及TNF的变化及意义 被引量:6

Changes and Significance of Serum Interleukin-2,6 and Tumor Necrosis Factor in Systemic Inflammatory Syndrome Induced by Children's Rotavirus Enteritis
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摘要 目的观察轮状病毒肠炎致全身炎症反应综合征(SIRS)患儿血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及肿瘤坏死因子(TNF)的变化。方法对78例轮状病毒肠炎患儿(其中40例SIRS患儿,38例非SIRS患儿)及健康对照组(43例)测定血清IL-2、IL-6及TNF的变化;对其中40例SIRS患儿治疗前后的IL-2、IL-6及TNF的变化进行比较。结果SIRS患儿血清IL-6及TNF含量明显高于非SIRS组和对照组,SIRS患儿血清IL-2含量明显低于非SIRS组和对照组,有显著性差异(P<0.01)。在SIRS患儿中随着异常指标的增加,IL-6、TNF升高,IL-2降低愈明显(P<0.01)。SIRS患儿经治疗,IL-6、TNF升高,IL-2降低明显好转。结论对SIRS的合理治疗对IL-6、TNF升高,IL-2降低有显著的逆转作用。 Objective To observe the changes of serum interleukin -2,6 (IL -2,6 )and tumor necrosis factor( TNF) in systemic inflammatory response syndrome(SIRS) induced by children's rotavirus enteritis. Methods Serum IL - 2, IL - 6 and TNF were detected in 78 children with rotavirus enteritis ( of which,40 cases were SIRS and 38 cases were non -SIRS), as well as in health control group(43 children). The changes of IL - 2, IL - 6 and TNF before and after treatment were compared among 40 cases with SIRS. Results Serum IL - 6 and TNF levels in SIRS group were higher apparently than those in non - SIRS groups and control group, and IL -2 level in SIRS group was lower apparently than that in non - SIRS groups and control group, indicating significant differences in comparison( P 〈 0.01 ). In SIRS group, the more the abnormal indexes were, the more apparently IL -6 and TNF were increased and IL -2 decreased (P 〈 0.01 ). After treatment in SIRS group, the increase of IL -6 and TNF and decrease of LI -2 were relieved apparently. Conclusion Rational treatment reverses the increased IL -6 and TNF and decreased IL -2 significantly in SIRS.
出处 《世界中西医结合杂志》 2009年第5期335-337,共3页 World Journal of Integrated Traditional and Western Medicine
关键词 全身炎症反应综合征 轮状病毒肠炎 白细胞介素-2 白细胞介素-6 Systemic inflammatory response syndrome ( SIRS ) Rotavirus enteritis Interleukin - 2 Interleukin - 6
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