摘要
核受体是一类配体依赖的转录因子，它们之间有相似的结构，在进化上来源于同一前体，它们和基础转录因子有直接的联系，与配体结合后，作用于其目标基因的特定应答元件上，从而活化特定基因的转录．核受体介导的转录活化需要有辅活化子（ｃｏａｃｔｉｖａｔｏｒ）和辅阻遏子（ｃｏｒｅｐｒｅｓｏｒ）的参与，这些辅活化子和辅阻遏子是有效的转录所必需的．它们能和核受体特异结合，并在核受体和基础转录因子之间发挥中介作用．目前发现普遍存在并在转录过程中具有重要作用的辅活化子有ＣＢＰ／Ｐ３００和ＳＲＣ１等，辅阻遏子有ＳＭＲＴ等．
Nuclear receptor belong to a superfamily of protein.Members of this family are characterized by similar three major structure region including a highly conserved DNA binding domain.Nuclear receptor bind to specific DNA sequence and control specific gene transcription.Recent data show that,in addtion to contacting to basal transcription factors,nuclear receptor inhibit or enhance transcription by recruiting the array of coactivator or corepressor.Coactivators are necessary for the efficient transcription.CBP/P300, SRC1and SMRT are the main coactivators and corepressor found so far.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1998年第3期222-226,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金国际合作和交流项目
关键词
核受体
转录因子
辅活化子
辅阻遏子
nuclear receptor, transcription factor, coactivator, corepressor
