摘要
目的评价辛伐他汀在短暂性脑缺血发作(TlA)患者颈动脉粥样硬化斑块和血脂水平的影响。方法52例有颈动脉粥样硬化斑块的TIA患者随机分为辛伐他汀组(简称他汀组)和对照组:他汀组口服辛伐他汀和阿司匹林6个月,对照组仅口服阿司匹林,治疗前后进行颈动脉超声检查.观察颈动脉内-中膜厚度(IMT)、动脉粥样硬化斑块面积、检测血脂水平,比较治疗6个月内两组患者脑血管事件的发生率。结果治疗后他汀组血胆固醇、低密度脂蛋白、甘油三脂水平比治疗前明显下降,高密度脂蛋白水平明显升高(均P<0.01);颈动脉IMT变薄及斑块面积减少,与对照组比较差异均有统计学意义(P<0.05～0.01);他汀组脑脑血管时间的发生率为9.7%,对照组为20.6%,两组间差异无统计学意义(P>0.05)。结论辛伐他汀不仅有调整血脂的作用,还具有抗脂质氧化、保护血管内皮等多种作用,并能消除或稳定TIA患者的颈动脉粥样硬化斑。
Objective To observe simvastatin on transient ischemic attack（T1A）in patients with carotid atherosclerosis and blood lipid levels and the impact of clinical efficacy. Methods 52 cases having carotid atheroselerosis TIA patients were randomly divided into the simvastatin group（statins） and the control group：statins and aspirin group of oral simvastatin for six months, the control group only oral aspirin before and after treatment for carotid ultrasound examination. Observation of the carotid artery-in the film thickness（ IMT）, atherosclerosis area, testing blood lipid levels, compared the treatment within six months of the two groups of patients with cerebral vascular incident rate. Results After treatment, the levels of blood cholesterol, low-density lipoprotein and triglyceride in statin group decreased significantly and the high-density lipoprotein increased significantly（all P 〈0.01）. Carotid IMT became thin and plaque size reduced. Compared with the control group,difference in the statin group were significant（ P 〈 0. 05 - 0. 01 ）. The rate of cerebral vascular time in the statin group was 9.7% and 20. 6% in the control group, there being no significant difference between the two groups （P 〉 0.05 ）. Conclusion Simvastatin not only adjusts the role of lipids, but also has the role of anti-lipid oxidation and vascular endothelial protection, and can eliminate or stabilize the carotid antherosclerosis plaue of TIA patients.
出处
《中国现代药物应用》
2009年第11期40-41,共2页
Chinese Journal of Modern Drug Application
