摘要
目的探讨老年冠心病、充血性心力衰竭患者对美托洛尔的耐受剂量。方法对照分析３０例老年前期及３２例老年冠心病、充血性心力衰竭患者。结果最佳耐受量，老年组２０．３±７．３ｍｇ／ｄ，老年前期组２５．２±８．０ｍｇ／ｄ（Ｐ＜０．０５）。心功能Ⅲ级及Ⅳ级者的耐受量老年组与非老年组比较、同组中Ⅲ级与Ⅳ级者比较差异均有显著性（均为Ｐ＜０．０５）。疗效，老年组、老年前期组总有效率分别为８４％及８７％。老年组发生不良反应３例，老年前期组均耐受良好。结论β阻滞剂可为治疗充血性心力衰竭的有效方法之一，其疗效与年龄无关；但耐受量与年龄和心力衰竭程度密切相关。
Objective To explore the tolerance dose for the aged patients with congestive heart failure (CHF) under treatment with metoprolol. Methods A contrast analysis is taken in 32 aged and 30 pre aged coronary artery disease patients with CHF. Results The best tolerance dose for aged group was 20 3±7 3mg/d, for pre aged group 25 2±8 0mg/d ( P <0 05). The differences of tolerance doses between aged and pre aged groups for both ventricular function grade Ⅲ and Ⅳ, and between ventricular function grade Ⅲ and grade Ⅳ in either the aged or the pre aged group were significant (all P <0 05). The observations on efficacy showed the overall response rate for aged group was 84% and 87% for pre aged group. Three patients in the aged group had sideeffects. All of the pre aged group showed good tolerance. Conclusions Beta blocker may be an effective measure in the treatment of coronary artery disease patients with CHF. Its efficacy is not related with patient's age, but the tolerance dose is closely related with age and severity of heart failure. So proper skill of its administration should be used in treatment of aged patients with severe heart failure.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
1998年第3期171-173,共3页
Chinese Journal of Geriatrics
