摘要
慢性乙型肝炎(chronic hepatitis B,CHB)患者免疫功能发生紊乱,导致持续性肝细胞损害,影响对病毒的清除能力.树突状细胞(dendritic cells,DCs)是体内最主要的抗原递呈细胞,激发机体能够针对外界病原体的侵入产生足够的免疫反应,其数量、功能正常与否直接影响机体的免疫应答.他不仅可以作为宿主抗病毒的功能细胞,也可以作为有利于病毒传播和逃避免疫损伤的载体.因此,对CHB状态下DCs性质的研究及功能提高途径的探索具有重要意义.
The immune function disorders in patients with chronic hepatitis B （CHB） lead to persistent damage of their liver cells and have impact on the ability to clear the virus. Dendritic cells （DCs） are the most important antigen-presenting cells in body. They help to generate sufficient immune response by the invasion of pathogens. The quantity and functionality of DCs directly correlate with the normal function of the host＇s immune response. Not only can DCs be resistant to the virus, but also serve as vehicles for the virus to spread and escape immune injury. Therefore the research on DCs and improving their function under the state of CHB is quite significant.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第11期1112-1116,共5页
World Chinese Journal of Digestology
