摘要
目的:比较美托洛尔与地尔硫卓治疗不稳定性心绞痛病人的疗效。方法:44例不稳定性心绞痛患者随机分成两组,一组给予美托洛尔6.25m g,口服,2次/天,另一组给地尔硫卓30m g,口服,3次/天,疗程均为1个月。结果:美托洛尔组的疼痛症状缓解,疼痛再发和心肌梗死的发生率减少均显著优于地尔硫卓组(P<0.05)。结论:小剂量美托洛尔选择性阻断1β受体,降低心肌的耗氧量,有对抗儿茶酚胺的心脏毒性作用,在预防心肌梗死及改善心绞痛症状上优于地尔硫卓,其长期效果仍需继续观察。
Objective：To investigate the curative effect of metoprolol compared with diltiazem in the patients with unstable angina pectoris. Methods：The 44 patients with unstable angina pectoris were randomly divided into two groups. The metoprolol group was given 6.25rag metoprolol, 2 times/d. The diltiazem group was given 30rag dihiazem, 3 times/d. The treatment course was a month. Results：The pain relief,pain recurrence and decrease in acute myocardial infarction in metoprolol group were more than those of diltiazem group （P 〈 0.05）. Conclusion：Minidose metoprolol can improve symptoms and decreases myocardium infarction.
出处
《黑龙江医药科学》
2009年第3期50-51,共2页
Heilongjiang Medicine and Pharmacy
关键词
美托洛尔
地尔硫卓
心绞痛
metoprolol
diltiazem
unstable angina pectoris
