小剂量胺碘酮联合缬沙坦治疗阵发性房颤的临床观察被引量：5

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摘要目的:探讨小剂量胺碘酮联合缬沙坦治疗心功能在Ⅲ级以下(除Ⅲ级)的阵发性房颤维持窦性心律的长期疗效。方法:将90例阵发性房颤患者随机分为胺碘酮组(Ⅰ组,n=45)和胺碘酮加缬沙坦组(Ⅱ组,n=45),治疗随访时间为1.5年,研究的一级终点为房颤复发。比较两组治疗后的窦性心律维持率以及治疗前与治疗后6、12、18个月的左心房内径。结果:治疗12个月后Ⅰ组左心房内径大于Ⅱ组(P<0.05)。试验终点时,Ⅰ组的窦性心律维持率为57.14%,Ⅱ组为80.95%,两组比较差异有统计学意义(P<0.05)。结论:小剂量胺碘酮联合缬沙坦治疗阵发性房颤优于单用胺碘酮,并且能够抑制左房扩大。

作者李璠

机构地区辽宁省辽阳市第三人民医院

出处《中国医药导报》 CAS 2009年第17期63-64,共2页 China Medical Herald

关键词房颤胺碘酮缬沙坦

分类号 R541.75 [医药卫生—心血管疾病]

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1柯丹,许春萱,林亚洲,张建成,陈林,林立芳,胡锡衷.心房颤动患者心房纤维化分子基础的临床研究[J].中华心血管病杂志,2005,33(5):459-463. 被引量：25
2殷跃辉,刘增长,吴近近,代引,苏立,兰先彬,凌智瑜,杨小渝,罗开良.胺碘酮与氯沙坦、培哚普利联合治疗阵发性心房颤动的前瞻、随机开放研究[J].中华心血管病杂志,2006,34(4):299-302. 被引量：72
3李建平,孙志刚,张薇,梁维民,黎莉,苗雅,张运.贝那普利在心房颤动复律后维持窦性心律中的作用及其对左房功能的影响[J].中华心血管病杂志,2005,33(1):102-102. 被引量：10
4Wu TJ,Ong JJ,Chang CM,et al.Pulmonary veins and ligament of marshall as sources of rapid activations in a canine model of sustained atrial fibrillation[J].Circulation,2001,103:1157-1163.
5Madrid AH,Bueno M,Rebollo M G,et al.Use of irbesartan to maintain sinus rhythm in patients with long-laating persistent atrial fibfillatioma prospective and randomized study[J].Circulation,2002,106:331-336.
6戚文航.血管紧张素受体拮抗剂与心房颤动[J].中华心血管病杂志,2004,32(11):1042-1043. 被引量：93

二级参考文献32

1Frustaci A, Chimenti C, Bellocci F, et al. Histological substrate of atrial biopsies in patients with lone atrial fibrillation . Circulation, 1997, 96: 1180-1184.
2Thomas H, Li H, Mangrum M, et al. Electrical, morphological, and ultrastructural remodeling and reverse remodeling in a canine model of chronic atrial fibrillation . Circulation, 2000, 102: 1454-1460.
3Li D, Shinagawa K, Pang L, et al. Effects of angiotensin converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure. Circulation,2001,104: 2608-2614.
4Wijffels MC, Kirchhof CJ, Dorland R, et al. Atrial fibrillation begets atrial fibrillation: a study in awake chronically instrumented goats. Circulation,1995,92:1954-1968.
5Yu WC, Lee SH, Tai CF, et al. Reversal of atrial electrical remodeling following cardioversion of long-standing atrial fibrillation in man. Cardiovasc Res,1999,42: 470-476.
6Ausma J,Van der Velden HM, Lenders MH, et al. Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goat. Circulation,2003,107:2051-2058.
7Allessie M, Ausma J, Schotten U. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res, 2002, 54: 230-246.
8Hoit BD. Matrix metalloproteinase and atrial structural remodeling. J Am Coll Cardiol, 2003 , 42:345-347.
9Kostin S, Klein G, Szalay Z, et al. Structural correlate of atrial fibrillation in human patients. Cardiovasc Res, 2002, 54: 361-379.
10Shinagawa K, Shi YF, Tardif JC, et al. Dymamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs. Circulation, 2002, 105: 2672-2678.