摘要
目的:研究静脉注射利多卡因对芬太尼诱导的咳嗽反应的影响。方法:择期行全麻手术病人60例,随机分为3组,Ⅰ组在芬太尼注射前1分钟静脉注射利多卡因(1 mg/kg),Ⅱ组在芬太尼注射前1分钟静脉注射利多卡因(2mg/kg),Ⅲ组为对照组。分别观察芬太尼注射后的咳嗽反射情况,咳嗽1-2次为轻微,3-4次为中等,5次以上为重度。结果:Ⅰ组、Ⅱ组和Ⅲ组咳嗽反应的发生率为分别为25%、30%和65%,Ⅰ组、Ⅱ组咳嗽反应的发生率明显低于Ⅲ组(P<0.05),Ⅰ组和Ⅱ组比较无明显差别(P>0.05)。结论:芬太尼注射前1分钟静脉注射利多卡因1mg或2mg可有效减轻芬太尼诱导的咳嗽反射;芬太尼注射前1分钟静脉注射利多卡因的量对减轻芬太尼诱导的咳嗽反射区别不大。
Fentanyl is commonly used as a pre-induction adjunct because of its quick onset,short duration of action, intense analgesia,and cardiovascular stability,but a pre-induction bolus dose of fentanyl elicits cough.Fentanyl-induced cough is common but has not been viewed as a serious anesthetic problem.Intravenous lidocaine suppresses the cough reflex during endotracheal intubation,
出处
《承德医学院学报》
2009年第2期131-133,共3页
Journal of Chengde Medical University
