摘要
活跃的糖酵解代谢是恶性肿瘤细胞显著的生化特征。即使在有氧条件下,恶性肿瘤细胞糖酵解代谢仍明显活跃,这一特殊生化表型,被称为Warburg效应。临床上已利用Warburg效应,通过正电子发射断层显像(PET)技术来诊断恶性肿瘤,而探索通过干预糖酵解代谢途径来治疗恶性肿瘤的策略正备受关注。本文就恶性肿瘤细胞糖酵解活跃的机制,War-burg效应在恶性肿瘤诊断及靶向性治疗中的作用作一综述。
The most striking biochemical phenotype of malignant tumor cells is their elevated glycolysis. Even in the presence of available oxygen, such an enhancement of glycolysis becomes known as the Warburg effect. Based on Warburg effect, positron emission tomography （PET） is widely used in the clinical diagnosis of cancers. Importantly, the therapeutic strategies targeting tumor bioenergetics are being explored. Our review is focused on mechanism of elevated glycolysis in malignant tumor cells, and the role of Warburg effect in diagnosis cancer and target treatment.
出处
《临床肿瘤学杂志》
CAS
2009年第5期470-473,共4页
Chinese Clinical Oncology
基金
国家自然科学基金资助(30873015)
