摘要
目的：探讨淋巴瘤、多发性骨髓瘤患者有无血栓前状态，判断病情，以其指导治疗。方法：采用放射免疫法、发色底物法等对４０例淋巴瘤、２４例多发性骨髓瘤的血小板表面α－颗粒膜蛋白、凝血酶原、凝血酶、血管性假血友病因子及抗凝血酶Ⅲ进行了测定。结果：前三项指标淋巴瘤组分别为４２．５％、３０％和４５％，多发性骨髓瘤组分别为６２．５％、２０．５％和５８．３％患者较正常升高。少数晚期淋巴瘤抗凝血酶Ⅲ含量下降。晚期淋巴瘤较早期易发生血栓前状态。结论：淋巴浆细胞系统恶性肿瘤常伴血栓前状态。
Objective:Prethrombotic state in patients with lymphoma and multiple myeloma was studied in order to judge the condition and direct the treatment.Methods:Radioimmunoassay,chromogenic substrate,etc were used to determine molecule number of platelet surface αgranule membrane protein (GMP140),Prothrombin (FⅡ),von willebrand factor (VWF),thrombin and anti thrombin (ATⅢ) in 40 patients with lymphoma and in 24 patients with multile myeloma (MM).Results:GMP140,FⅡ and thrombin increased,being 42.5%,30%,45% respectively in patients with lymphoma and 62.5%,21.5%,58.3% in patients with MM.VWF increased in more than half patients.Antigen and activity of ATⅢ decreased in a few advanced lymphoma patients.Conclusion:These data suggest that lymphomaplasmacyte system malignant tumor are often associated with prethrombotic state.The severity of this state is closely related to period of disease.
出处
《白求恩医科大学学报》
CSCD
1998年第3期283-284,共2页
Journal of Norman Bethune University of Medical Science
关键词
血栓前状态
淋巴瘤
多发性骨髓
颗粒膜蛋白
prethrombotic state
lymphoma
multiple ,myeloma
αgranule membrane preotein
thrombin
