摘要
目的探讨中国汉族广东籍人群中ＣＹＰ２Ｄ６、ＧＳＴＭ１的遗传多态性与肺癌易感性关系。方法采用病例—对照研究方法，用ＰＣＲ检测ＣＹＰ２Ｄ６、ＧＳＴＭ１的基因型，限制性酶切电泳鉴定ＣＹＰ２Ｄ６点突变。结果病例组与对照组间未发现ＣＹＰ２Ｄ６多态性分布差异，而ＧＳＴＭ１多态性存在分布差异，病例组为５８．７％，对照组为３５．７％（Ｐ＜０．０５），ＯＲ值为２．５６（１．１１－２．４４）。结论ＣＹＰ２Ｄ６Ｇ－Ａ突变与肺癌易感性未见有联系。
Objective To evaluate the relationship between CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility among Cantonese in China. Methods In a case control study, PCR was used to identify CYP2D6 and GSTM1 genotypes and restriction enzyme BstNI was used to identify a specific point mutation of CYP2D6. Results Between lung cancer patient group and normal control group CYP2D6 genetic polymorphism did not show frequency distribution differences but that of GSTM1 did (58.7% n =46, 35.7%, n =70, P < 0.05)OR =2.56(1.11～2.44). Conclusion There is no association between CYP2D6 G-A mutation and lung cancer susceptibility, while individuals with GSTM1-/-genotype are susceptible to lung cancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1998年第3期185-186,共2页
Chinese Journal of Oncology
基金
美国中华医学基金
关键词
肺肿瘤
疾病易感性
细胞色素
P450
遗传多态性
Lung neoplasms Disease susceptibility Cytochrome p450 Genotype Polymorphism(Genetics)
