卡培他滨联合奥沙利铂治疗晚期大肠癌的临床观察被引量：2

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摘要目的:对比观察卡培他滨联合奥沙利铂及亚叶酸钙、氟尿嘧啶联合奥沙利铂治疗晚期大肠癌的近期疗效和毒副反应。方法:56例晚期大肠癌随机分为XELOX组和OLF组。XELOX组28例,采用奥沙利铂、卡培他滨联合化疗;OLF组28例,采用奥沙利铂、亚叶酸钙、氟尿嘧啶联合化疗。两组均21d重复,2个周期后评价疗效和毒副反应。结果:XELOX组近期有效率50.0%,OLF组近期有效率42.9%,差异无统计学意义(P>0.05)。XELOX组白细胞减少、恶心、呕吐、腹泻和腹痛的毒副反应发生率均低于OLF组,差异有统计学意义(P<0.05)。结论:卡培他滨联合奥沙利铂是治疗晚期大肠癌的有效化疗方案,较亚叶酸钙、氟尿嘧啶联合奥沙利铂方案具有给药方便、毒副反应轻的优点,患者更易接受。

作者张红巧吴敏王丽娟巴楠

机构地区郑州大学第五附属医院

出处《陕西医学杂志》 CAS 2009年第6期726-727,共2页 Shaanxi Medical Journal

关键词大肠肿瘤/药物疗法氟尿嘧啶/治疗应用 @卡培他滨 @奥沙利铂

分类号 R735.34 [医药卫生—肿瘤] R979.1 [医药卫生—药品]

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1Hoff PM,Ansari R,Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first line treatment in 605 patients with metastatic colorectal cancer. Results of a randomized phase Ⅲ study. J Clin Oncol,2001,19 (8) : 2282-2292.
2向作林,吴铮,曾昭冲,李文如,王健,陈刚.卡培他滨联合奥沙利铂治疗晚期大肠癌的疗效观察[J].中国临床医学,2004,11(3):386-387. 被引量：10
3Jim C ,Josep T ,Chris T ,et al. XELOX(Capecitabine Plus Oxalipltin):Active First-Line Therapy for Patients with Metastatic Colorectal Cancer. Journal of Clinical Oncology, 2004,22 : 2084-2091.

二级参考文献7

1Zeuli M, Costanzo ED, Sdrobolini A, et al. Capecitabine and oxaliplatin in advanced colorectal cancer: a dose - finding study.Ann Oncol, 2001,12(12): 1737-1741.
2Schuller J, Cassidy J, Dumont E, et al. Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother Pharmacol, 2000,45(4) :291-297.
3Sumpter K, Harper- Wynne C, Cunningham D, et al. Oxaliplatin and capecitabine chemotherapy for advanced colorectal cancer:a single institution's experience. Clin Oncol (R Coll Radiol),2003,15(5) :221-226.
4Scheithauer W, Kornek GV, Raderer M, et al. Intermittent weekly high-dose capecitabine in combination with oxaliplatin:a phase Ⅰ/Ⅱ study in first - line treatment of patients with advanced colorectal cancer. Ann Oncol, 2002, 13 (10) : 1583 ～1589.
5Twelves CJ, Cassidy J. Which endpoints should we use in evaluating the use of novel fluoropyrimidine regimens in colorectal cancer. Br J Cancer, 2002,86(11) :1670- 1676.
6Scheithauer W, Kornek GV, Raderer M, et al. Randomized multicenter phase Ⅱ trial of two different schedules of capecitabine plus oxaliplatin as first - line treatment in advanced colorectal cancer. J Clin Oncol, 2003,21(7):1307～1312.
7Twelves C. Can capecitabine replace 5 - FU/leucovorin in combination with oxaliplatin for the treatment of advanced colorectal cancer?Oncology (Huntingt), 2002,16( 12 Suppl No 14): 23 - 26.