摘要
目的探讨中国汉族人群中抑郁症患者与5-羟色胺2A(5-HT2A)受体基因-1438A/G多态性之间的关系。方法采用高温连接酶检测反应法,检测254例抑郁症患者和231例正常对照者的5-HT2A受体基因-1438A/G多态性的基因型和等位基因分布。结果(1)5-HT2A受体基因-1438A/G多态性的基因型和等位基因频率在患者组和对照组的分布差异无统计学意义(P>0.05)。(2)患者组-1438A/G多态性的三种基因型之间的汉密尔顿抑郁量表总分和各因子分的差异无统计学意义(P>0.05)。(3)-1438A/G多态性基因型及等位基因在性别和有无精神病疾病家族史之间无显著差异(P>0.05)。结论在中国汉族人群中未发现5-HT2A受体基因-1438A/G多态性与抑郁症存在关联。
Objective To investigate the association between major depression and the - 1438A/G poly- morphism of serotonin receptor 2A gene in a Chinese HaM population. Methods Using the ligase detection reac- tion, - 1438A/G polymorphism was typed in 254 patients with major depression and 231 healthy control subjects. Results （ 1 ） The genotype distributions and allele frequencies of - 1438A/G polymorphism wcrc not significantly different between the patients and controls （ P 〉 〉 0.05 ）. （2） The total scores and factor scores of HAMD were no significant difference in different genotypes groups in patients （P 〉 0. 05 ） . （3） The genotype distributions and al- lele frequencies of - 1438A/G polymorphism were not significantly different between sex and family history of mental disorders （ P 〉 0.05 ） . Conclusion Association of major depression and the - 1438A/G polymorphism of se- rotonin receptor 2A gene was not founded in this study.
出处
《国际精神病学杂志》
2009年第2期65-68,共4页
Journal Of International Psychiatry
