期刊文献+

严重创伤感染致肠道免疫屏障损伤的研究进展 被引量:3

Study Of Severe Wound And Infection Leading To Intestinal Immunization Barrier Hurt
下载PDF
导出
摘要 肠道不仅是消化器官,也是人体内最大的免疫器官。在严重创伤、感染等应激情况下,肠道最先且最易受累,常表现为黏膜糜烂、出血上皮细胞坏死、脱落,肠道局部微循环障碍、缺血再灌注损伤和免疫屏障损伤。肠免疫屏障损伤可进一步导致多器官功能衰竭的发生。因此,近年来有关脓毒症与多器官功能障碍综合征(multiple organ dysfunction syndrome MODS)的胃肠道学说将危重疾病状态下的胃肠道黏膜屏障功能损害称为全身炎症反应综合征(systemic inflammatory response syndrome S I R S)向M O D S和多器官功能衰竭(multiple organ failureM O F)转化的始动器官。 Intestine is not only the biggest digestive organ but also the biggest immune organ .When our body gets severe hurt and infection ,the intestine can be destroyed. Though they don't injure the intestine and stomach directly.In this situation , the intestine can be bleeding , cell death , ischemical reperfusion injury and Intestinal immunization barrier hurt ,which can lead to MODS. Therefore some people recently believe that Imestinal immunization barrier hurt is the origin of systemic inflammatory response syndrome and multiple organ failure.
出处 《疾病监测与控制》 2009年第6期383-384,358,361,共4页 Journal of Diseases Monitor and Control
关键词 肠道 特异性免疫解障 非特异性免疫屏障 intestine specific immunization barrier nonspecific immunization barrier
  • 相关文献

参考文献12

二级参考文献29

  • 1马利 肖光夏 等.出血性休克与肠源性感染[J].第三军医大学学报,1990,12:15-17.
  • 2[1]Deitch EA.Simple intestinal obstruction causes bacterial transloca tion in man[J].Arch Surg,1989,124(6):699-70l.
  • 3[2]Wells CL,Maddaus MA,Simmons RL.Role of the macrophage in the translocation of intestinal bacteria [J].Arch Surg,1987,122 (1):48-53.
  • 4[3]Deitch EA,Bridges W,Berg R.Hemorrhagic shock-induced bacterial ranslocation:the role ofneutrophils and hydroxyl radicals [J].JTrauma,1990,30(8):942-51.
  • 5[4]Berg RD.Bacterial translocation from the gastrointestinal tract[J] .Med,1992,23(3-4):217-44.
  • 6[5]Viney JL.Immune fate decided by dendritic cell provocateurs [J] Trends Immunol,2001,22(1):8-10.
  • 7[6]Basu A,Chakrabarti G,Saha A,et al.Modulation ofCD1 IC+ splenicdendritic cell functions in murine visceral leishmaniasis:correlationwith parasite replication in the spleen[J].Immunology,2000,99(2):305-13.
  • 8[7]Fryer J,Grant D,Jiang J.Influence of macrophage depletion on bacterial translocation and rejection in small bowel transplantation [J].Transplantation,1996,62(5):553-9.
  • 9[8]Ding JW,Anderson R,Soltesz VL.Inhibition of bacterial translocation in obstructive jaundice by muramyl tripeptide phoshatidylethanolamine in the rat[J].J Hepatol,1994,20(6):720-8.
  • 10Jiang H,Cell Immunol,1996年,167卷,293页

共引文献99

同被引文献29

引证文献3

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部