摘要
目的从厚朴粗提物中分离纯化和厚朴酚与厚朴酚。方法将厚朴酚两羟基用缩酮保护,再用正己烷重结晶分离纯化。结果一步反应分离得到和厚朴酚与厚朴酚,其纯度大于95%,总提取率为82%。结论所用方法简便易行,可放大生产。
OBJECTIVE To purify honokiol and magnolol from crude extracts. METHODS The hydroxyl groups of magnolol were protected using ketol reaction and the products were purified by recrystallization from hexane. RESULTS The content of both honokiol and magnolol was above 95% after one step and the average extraction yield was above 82%. CONCLUSION The purification procedure was carried out successfully by this method, which was proved to be easy to handle and scale up.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2009年第3期274-275,共2页
West China Journal of Pharmaceutical Sciences
