摘要
对烯丙基作为核苷糖环上羟基保护基进行了研究．烯丙基可用于核糖羟基的保护，用ＰｄＣｌ２可脱除核苷糖环上烯丙基，保护及脱保护都很简便．ＰｄＣｌ２还可脱除核苷糖环５－ＯＨ常用的保护基对甲氧基三苯甲基及二对甲氧基三苯甲基．控制适当的条件，ＰｄＣｌ２既能够选择性地脱除对甲氧基三苯甲基或二对甲氧基三苯甲基，又可同时脱除保护糖环羟基的烯丙基．
The possibility of allyl as the protection group of the hydroxyls in nucleosides was studied. Allyl bromide can react with thymidine and adenosine in the presence of NaOH to give O allyl protected nucleosides in good yield. PdCl 2 can be used as a reagent for the deprotection. It was found that PdCl 2 can selectively deprotect the p methoxytrityl, di p methoxytrityl or both of the p methoxytrityl, di p methoxytrityl and allyl group.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第5期728-731,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
烯丙基
核苷糖
羟基保护
保护
核糖羟基
Allyl, p Methoxytrityl, Di p methoxytrityl, PdCl 2, Hydroxyls of ribose
