摘要
目的比较应用1.8%的高渗氯化钠葡萄糖溶液(HEGS)和0.9%的等渗氯化钠葡萄糖溶液(IEGS)进行烧伤早期抗休克治疗对补液量及肺血管通透性的影响。方法采用Beagle犬35%TBSAⅢ度烧伤模型,随机分为高渗盐糖溶液复苏组(H组)、等渗盐糖溶液复苏组(Ⅰ组)和对照组(C组)。分别于伤前及伤后0.5、1、2、4、6、8、24h测血管外肺水(EVLW)、肺血管通透性指数(PVPI),全身血浆容量(PV)及血浆渗透压(OPP),伤后24h处死,取肺脏测量含水量。结果H组从伤后3～4h开始,EVLW、PVPI显著低于Ⅰ组(P<0.05或P<0.01);H组肺脏含水量明显低于I组(P<0.05);H组从伤后2h开始OPP明显高于Ⅰ组(P<0.05或P<0.01);H组和I组PV无明显差别(P>0.05),但伤后2h开始均高于C组(P<0.01)。结论HEGS进行烧伤早期复苏,能减少补液量,降低肺血管通透性,减轻肺脏水肿程度。其复苏效果优于IEGS。
Objective To compare the effects of hypertonic electrolyte glucose solution （HEGS） with isosmotic electrolyte glucose solution（IEGS） as different resuscitation fluids on volume of fluid replacement and pulmonary vasopermeability at early stage Of burn shock. Methods Beagles inflicted by 35% TBSA Ⅲ degree burn were employed as the model. 18 dogs were randomly divided into three groups with 6 in each group ,i. e. hypertonic electrolyte glucose solution group（ H group）, isosmotic electrolyte glucose solution group（I group） and control group（ C group）. The EVLW, PVPI and OPP were tested 0.5h, 1h,2hs,4hs,6hs,ghs ,24hs before and after burn. Beagles were killed .and pulmonary water content was measured 24hs after bum. Results Compared to those in I group,the EVLW and PVPI in H group decreased significantly since 3-4hs after burn（ P 〈0.05 or P 〈0.01）. The pulmonary wa- ter content in H group is obviously lower than that in I group（P 〈0.05）. The OPP in H group is much higher than that in I group since 2hs after burn（ P 〈 0.05 or P 〈 0.01）. The PV in H group and I group have no significant discrepancy（ P 〉 0.05 ）, but higher than that in C group since 2hs after burn（P 〈 0.01 ）. Conclusion Using HEGS as a resuscitation fluid at early stage of burn shock provide a pathway to reducing volume of fluid replacement, decreasing pulmonary vasopermeability and mitigating edema ot lung. HEGS have better：resuseitation effect than IEGS.
出处
《临床军医杂志》
CAS
2009年第3期343-345,共3页
Clinical Journal of Medical Officers
基金
全军医药卫生"十一.五"重点课题(06Z054)
关键词
烧伤
液体复苏
高渗盐
肺水肿
burn
fluid resuscitation
hypertonic saline
edema of lung
