摘要
目的观察非增殖期糖尿病视网膜病变(DR)患者服用羟苯磺酸钙药物治疗前、后的眼底变化,评估其对DR的疗效。方法我院DR78例(146眼),按其眼底病变程度分为早期和中期。将早、中期患者各分为2组:试验组和对照组。其中早期病变的试验组为A组(23例44眼),对照组为B组(18例35眼);中期病变的试验组为C组(21例35眼),对照组为D组(16例32眼)。试验组服用羟苯磺酸钙3个月。所有患者用药前后进行视力、眼压、散瞳眼底照相、眼底血管荧光造影,并进行对比分析。结果羟苯磺酸钙治疗后,A组较B组眼底改善者明显增多,有效率高(P<0.05);C组较D组眼底改善者明显增多,有效率高(P<0.05);A组较C组眼底改善者明显增多,有效率高(P<0.05)。结论羟苯磺酸钙对非增殖期DR具有改善和稳定病变的作用,对早期病变疗效更为显著。
Objective To observe the therapeutic effect of calcium dobesilate on nonproliferative diabetic retinopathy（DR）. Methods 78 diabetic patients （146 eyes ） were selected. Patients were divided into experimental group and control group. Nonage experimental group was named group A（ 23 eases ,44 eyes）, nonage control group was named group B （18 cases, 35 eyes）, metaphase experimental group was named group C （21 eases,35 eyes）, and metaphase control group was named group D （16 eases, 32 eyes）. The patients in experimental group A and group C took domestic calcium dobesilate for 12 weeks. Three months before and after treatment, the patients＇ vision, intraocular pressure, the condition of retina, FFA were observed and compared. Results After treatment the number of patients with improvement of eye ground in group A was significantly more than that in group B, so was the effective rate（ P 〈 O. 05 ）. The number of patients with improvement of eye ground in group C was significantly more than that in group D, so was the effective rate （ P 〈 0.05 ）. The number of patients with improvement of eye ground in group A was significantly more than that in group C, so was the effective rate（ P 〈 0.05 ）. Conclusion Calcium dobesilate is effective in treating nonproliferative DR, which is more effective for early pathological changes.
出处
《河北医药》
CAS
2009年第9期1039-1040,共2页
Hebei Medical Journal
