摘要
目的提高医务人员对耐甲氧西林金黄色葡萄球菌（MRSA）医院感染的认识，指导临床合理用药。方法调查2008年3—6月医院重症监护病房（ICU）发生伴有MRSA感染的死亡病例，分析2007年1月-2008年12月MRSA细菌谱及耐药情况。结果3例死亡病例均检出MRSA，药敏试验显示对万古霉素敏感，对其他抗菌药物耐药；2007年1月-2008年12月共检出MRSA30株，药敏试验显示：对青霉素、红霉素、头孢唑林、苯唑西林耐药率达100．0%；对环丙沙星、克林霉素、左氧氟沙星、复方新诺明等耐药率为66．7％～87．0％。结论MRSA对抗菌药物耐药严重，易侵袭营养不良、大手术创伤、术后长时间使用呼吸机的患儿，应早期使用敏感药物，并从医院感染管理、医疗护理管理等多学科的角度，预防与控制MRsA医院感染暴发。
OBJECTIVE To investigate the hospital acquired MRSA infection death cases and drug-resistance to improve the proper clinical utilization of antibiotics. METHODS The clinical data of the death cases in ICU wards from Mar 2008 to Jun 2008, and the drug sensitivity and resistance results of MRSA from Jan 2007 to Dec 2008 were analyzed retrospectively. RESULTS MRSA isolated from all of the three death cases were susceptible to vancomycin and unsusceptible to other antibiotics. Thirty MRSA strains were isolated from Jan 2007 to Dec 2008. Drug sensitivity test showed 100% drug-resistance rate to penicillin, erythromycin, cefazolin and oxacillin; 66.7%-87. 0% drug-resistance rate to ciprofloxacin, clindamycin, levofloxacin, and sulfamethoxazole compound. CONCLUSIONS High drug-resistance rate of MRSA to commonly used antibiotics is found. MRSA is usually infected in patients with malnutrition, major surgery or infants long term using ventilator. Sensitive antibiotics should be used in early time and regulations from aspects of hospital infection control, medical administration and nursing management also be carried out to prevent and control the prevalence of MRSA bacteria.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第12期1584-1585,共2页
Chinese Journal of Nosocomiology
