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Apelin在心血管系统及脂肪胰岛轴中的作用

Function of Apelin in Cardiovascular System and Adipoinsular Axis
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摘要 Apelin是孤儿G蛋白耦联受体APJ的的内源性配体,也是由脂肪细胞分泌的一个新的脂肪细胞因子。其通过与APJ关键词:apelin;APJ;心血管系统;脂肪胰岛轴受体结合发挥多种生物学效应,如舒张/收缩血管、增强心肌收缩力、调节体液平衡、调节胰岛素分泌等。现就其在心血管系统及脂肪胰岛轴中的作用做简要综述。 Apelin is an endogenous ligand for the orphan G protein-coupled APJ receptor, and is also a newly discovered adipocytokine secreted by adipoeytes. Apelin has multiple biological effects such as, dilating/contracting vessels, regulating body fluid homeostasis, and modulating insulin secretion, all of which acts through the APJ receptor. This article briefly reviews the function of apelin in the cardiovascular system and adipoinsular axis.
作者 岳洪峰 杨进刚 胡大一
机构地区 首都医科大学附属北京同仁医院 北京阜外心血管病医院 北京大学人民医院
出处 《心血管病学进展》 CAS 2009年第3期499-502,共4页 Advances in Cardiovascular Diseases
关键词 APELIN APJ 心血管系统 脂肪胰岛轴 apelin APJ cardiovascular system adipoinsular axis
分类号 R33 [医药卫生—人体生理学]
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参考文献27

  • 1Tatemoto K,Hosoya M,Habata Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J].Biochem Biophys Res Commun,1998,251(2):471-476.
  • 2Tatemoto K.Search for an endogenous ligand of the orphan G protein-coupled receptor-discovery of apelin,a novel biologically active peptide[J].Nippon Rinsho,2000,58(3):737-746.
  • 3Hosoya M,Kawamata Y,Fukusumi S,et al.Molecular and functional characteristics of APJ.Tissue distribution of mRNA and interaction with the endogenous ligand apelin[J].Biol Chem,2000,275(28):21061-21067.
  • 4Reaux A,de Mota N,Skultetyova I,et al.Physiological role of a novel neuropeptide,apelin,and its receptor in the rat brain[J].J Neurochem,2001,77:1085-1096.
  • 5Kawamata Y,Habata Y,Fukusumi S,et al.Molecular properties of apelin:tissue distribution and receptor binding[J].Biochim Biophys Acta,2001,1538:162-171.
  • 6Tatemoto K,Takayama K,Zou MX,et al.The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism[J].Regul Pept,2001,99:87-92.
  • 7Lee DK,Saldivia VR,Nguyen T,et al.Modification of the terminal residue of apelin-13 antagonizes its hypotensive action[J].Endocrinology,2005,146(1):231-236.
  • 8Szokodi I,Tavi P,Foldes G,et al.Apelin,the novel endogenous ligand of the orphan receptor APJ,regulates cardiac contractility[J].Circ Res,2002,91:434-440.
  • 9O' Dowd BF,Heiber M,Chan A,et al.A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome Ⅱ[J].Gene,1993,136(1-2):355-360.
  • 10Masri B,Knibiehler B,Audigier Y.Apelin signaling:a promising pathway from cloning to pharmacology[J].Cell Signal,2005,17(4):415-426.

二级参考文献15

  • 1Moore J P,Kitchen S G,Pugach P,Zack A.The CCR5 and CXCR4 coreceptors-central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection[J].AIDS Res Hum Retrovir,2004,20(1):111-26.
  • 2Reaux A,De M N,Skultetyova I,et al.Physiological role of a novel neuropeptide,apelin,and its receptor in the rat brain[J].J Neurochem,2001,77(4):1085-96.
  • 3Taheri S,Murphy K,Cohen M,et al.The effects of centrally administered apelin-13 on food intake,water intake and pituitary hormone release in rats[J].Biochem Biophys Res Commun,2002,291(5):1208-12.
  • 4Katugampola S D,Maguire J J,Matthewson S R,Davenport A P.[^(125)I]-[Pyr(1)] Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man[J].Br J Pharmacol,2001,132(6):1255-60.
  • 5Ishida J,Hashimoto T,Hashimoto Y,et al.Regulatory roles for APJ,a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo[J].J Biol Chem,2004,279(25):26274-9.
  • 6Tatemoto K,Takayama K,Zou M X,et al.The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism[J].Regul Pept,2001,99(2-3):87-92.
  • 7Szokodi I,Tavi P,Foldes G,et al.Apelin,the novel endogenous ligand of the orphan receptor APJ,regulates cardiac contractility[J].Circ Res,2002,91(5):434-40.
  • 8Gábor F,Ferenc H,István S,et al.Circulating and cardiac levels of apelin,the novel ligand of the orphan receptor APJ,in patients with heart failure[J].Biochem Biophys Res Commun,2003,308(3):480-5.
  • 9Chen M M,Ashley E A,Deng D X,et al.Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction[J].Circulation,2003,108(12):1432-9.
  • 10Smith P K,Krohn R I,Hemanson G T,et al.Measument of protein using bicinchominic acid[J].Anal Biochem,1985,150(1):76-85.

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心血管病学进展
2009年 第3期

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