摘要
以(NH4)2[Mo4O13]·2H2O,NiCl2·6H2O和2-(1H-吡唑-3-基)吡啶为原料,通过水热方法合成了一个新颖的[Ni(C8N3H7)3]4[Mo8O26]2·7H2O超分子化合物.采用元素分析、红外光谱和单晶X射线衍射法表征了该无机-有机杂化配合物的结构.晶体解析表明,该化合物同时含有α-[Mo8O26]4-和β-[Mo8O26]4-,在[Ni(C8N3H7)3]2+阳离子和[Mo8O26]4-阴离子之间通过氢键作用结合,在[Ni(C8N3H7)3]2+阳离子之间通过芳香环的π-π堆积作用连接,两种[Mo8O26]4-阴离子作为客体共存于一个具有三维蜂窝状的超分子结构中.同时研究了该化合物对人卵巢癌细胞SK-OV-3、肺癌细胞A549、宫颈癌细胞Hela和乳腺癌细胞MCF-7等细胞的体外抗肿瘤活性.结果表明,该化合物对3种不同来源的肿瘤细胞均有一定的增殖抑制作用,其中对MCF-7细胞的IC50值为6.48μmol/L,具有进一步研究的价值.
A novel supramolecular compound with the formula [ Ni （ C8 N3 H7 ） 3 ] 4 [ MO8O26 ] 2 7 H2O was synthesized by the hydrothermal reaction of （ NH4 ） 2 [ Mo4O13 ] · 2H2O, NiCl2 · 6H2O and [ 2-（ 1H-pyrazol-3- yl）-pyridine ]. The inorganic-organic hybrid material was characterized by IR spectroscopy, elemental analysis and single-crystal X-ray diffraction. The results of X-ray diffraction indicate that the title complex contains both α- and β-octamolybdates. Leading to the connection between the [ Ni （Cs N3 H7 ）3 ] ^2 ＋ complex cation and [ Mo8O26 ]^4- through hydrogen bonding interactions, and the connection between the complex cation [ Ni （ Ca N3 H7 ） 3 ] ^2 ＋ groups through π-π stacking interactions between aromatic rings, two kinds of octamolybdate anions as guests were accommodated in a 3D ＂honeycomb＂ host supramolecular network. Therefore, in vitro anti-tumor activity of the compound on human ovarian cancer cells SK-OV-3, human lung cancer cells A549, human cervical cancer cells Hela and human breast cancer cells MCF-7 was studied. The results show that the compound has a certain degree of growth inhibition to three different sources of tumor cells. In particular, the IC50 value to the MCF-7 cells is 6. 48 μmol/L, it shows that the compound has the value for further study.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2009年第6期1075-1079,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20671016)
吉林省教育厅“十一五”自然科学项目(批准号:2006124)资助
关键词
水热合成
钼-氧簇合物
抗肿瘤活性
体外实验
Hydrothermal synthesis
Molybdenum-oxygen cluster
Anti-tumor activity
in vitro test
