摘要
原因不明复发性流产(URSA)是近年来对自然流产研究的重点,免疫因素是导致自然流产反复发作的重要原因。在妊娠胚胎发育过程中,子宫蜕膜局部聚集了多种免疫活性细胞,其作用的变化直接影响到妊娠发展。免疫活性细胞产生的不同细胞因子有各自不同的作用,如果细胞因子间平衡关系被破坏也会导致流产的反复发生。自身免疫性疾病使妊娠妇女免疫机制亢进或同种免疫的保护性抗体缺乏,同样是流产的重要原因之一。
The research on spontaneous abortion emphasizes on unexplained recurrent spontaneous abortion in recent years. Immune factor is a important reason leading to recurrent spontaneous abortion. Firstly, many kinds of i,nmunocompetent cells congregate on the local uterine decidua during the evolution of embryo. The changes of their functions influence the development of pregnancy. Secondly, the different cytokines produced by the immunocompetent cells have their respective various functions. If the balance relations among the cytokines are destroyed, the spontaneous abortion would occur recurrently. Thirdly, the immune mechanism of pregnancy are at hypcrfunctional state due to the autoimmune diseases, and meanwhile, the deficiency of alloimmune protective antybody is also one of the important reasons for the spontaneous abortion.
出处
《国际妇产科学杂志》
CAS
2009年第3期193-195,共3页
Journal of International Obstetrics and Gynecology
关键词
复发性流产
细胞免疫
细胞因子
免疫抗体
Recurrent spontaneous abortion
Cellular immunity
Cytokine
Immune antibody
