摘要
目的:Mg2+对脑组织的细胞代谢和调节功能作用已受到重视,现研究颅脑外伤(TBI)后早期补充硫酸镁对TBI的治疗意义。方法:将94例重型TBI患者随机分为硫酸镁组(n=32)、硫酸镁+利多卡因组(n=32)及对照组(n=30),硫酸镁组除常规治疗外还给予硫酸镁2 g(16 mmol/L)稀释至100 ml于15 min内静脉推注,并以硫酸镁7.8 g(65 mmol/L)稀释至500 ml静脉滴注24 h;硫酸镁+利多卡因组,除了上述方法应用硫酸镁外,加用利多卡因12mg/(kg.h)静脉维持24 h;对照组不补充硫酸镁或利多卡因,其余治疗同其他组。检测所有患者入院当天及第3 d血镁水平、入院当天和入院第7 d的血神经元烯醇化酶(NSE)含量,6个月后以格拉斯哥结果评分(GCS)来评估各组治疗结果。结果:各组重型TBI患者在受伤后第7 d时的血NSE水平无显著差异,伤后6个月的GCS评分无显著差异。结论:未发现TBI后早期补充硫酸镁能明显改善重型TBI的治疗作用。
Objective：The regulatory effects of magnesium on cellular metabolism in brain tissue have been emphasized. The early use of magnesium sulfate （MgSO4 ） in the treatment of traumatic brain injury （TBI）. Methods： Ninety -four severe TBI patients were divided randomly into Groups A （MgSO4）, B （MgSO4 ＋ lidocaine） and C （normal control）. Group A received 15 -minute intravenous injection of MgSO4 2 g （ 16 retool） diluted to 100ml, followed by 24 - hour intravenous interjection of MgSO4 7.8 g （65 mmol） diluted to 500 ml. Group B, in addition to the above administration, were given intravenous injection of lidocaine 1 mg/kg/h for 24 hours. We determined the level of blood Mg2 ＋ at admission and 3 days after it and plasma neurone specific enolase （NSE） at admission and 1 week after injury, and conducted Glasgow Outcome Scale （GOS） assessment 6 months after injury for all the patients. Results ： The 1 - week plasma NSE level and 6 - month GOS showed no significant statistical differences among different groups of patients. Conclusion： Our study failed to reveal apparent improvement in the severe TBI patients after early administration of MgSO4.
出处
《医学研究生学报》
CAS
2009年第5期490-492,共3页
Journal of Medical Postgraduates
基金
上海市浦东新区社会发展局卫生科技发展基金资助项目(批准号:Pw2004A-16)
