摘要
内脏脂肪素(visfatin)是新近发现的由内脏脂肪组织分泌的一种脂肪细胞因子,与前B细胞集落增强因子(PBEF)结构相似,是由473个氨基酸组成的相对分子质量为52 000的多肽。在骨髓、肝、肌肉等多种组织中均有表达。可结合并激活胰岛素受体,并模拟胰岛素作用,促进脂肪组织分解、合成和蓄积,与肥胖相关。能促进血管平滑肌细胞成熟,参与炎症反应及细胞分化和凋亡过程。visfatin对糖脂代谢的调节作用及其他多种功能参与相关疾病的发病机制。对visfatin的深入研究可能为疾病的治疗提供新的靶点。
Visfatin is a recently discovered adipokine secreted by visceral adipose tissue, corresponds to pre-B cell colony-enhancing factor （PBEF）, which is composed of 473 amino acid coding a 52kDa polypeptide and expressed in bone marrow, liver, muscle and so on. Visfatin binds and activates the insulin receptor, exerting insulin-mimetic effects; promotes adipose tissue to differentiate, synthesis and accumulate, which is correlated with obesity ; promote vascular smooth muscle cell to mature, participating in the processes of inflammatory response and cell differentiation and apoptosis. The multifunction of visfatin increases new contents of correlated disease pathogenesis and new targets of disease management.
出处
《医学研究生学报》
CAS
2009年第5期552-557,共6页
Journal of Medical Postgraduates
基金
黑龙江省高等学校骨干教师创新计划基金资助(批准号:1054G024)
