摘要
ｆｅｃｔｓｏｆｃｉｃｌｏｓｐｏｒｉｎｏｎｗｈｏｌｅｂｌｏｏｄｃｈｅｍｉｌｕｍｉｎｅｓｃｅｎｃｅｏｆｒｅｎａｌｔｒａｎｓｐｌａｎｔｐａｔｉｅｎｔｓＣＨＥＮＳｈｕＹｕａｎ１，ＬＩＵＳｈｉＴｉｎｇ，ＨＯＵＬｉａｎＢｉｎｇ，ＣＨＥＮＺｈｉＬｉａｎｇｇ...
AIM: To examine the possible inhibitory role of ciclosporin (Cic) on luminol dependent chemiluminescence (CL) of whole blood in renal transplant patients. METHODS: Luminol dependent CL was used to measure active oxygen species generation in respiratory burst of whole blood stimulated by zymosan A. Fluorescence polarization immunoassay was used to monitor the blood concentration of Cic. RESULTS: CL values of Cic group ( n =50) decreased in comparison with those of normal group ( n =10) ( P <0 01). The blood concentration of Cic was negatively related to CL value ( P <0 01). The serum of renal transplant patients directly inhibited respiratory burst of peritoneal macrophages of rats in a concentration dependent manner. CONCLUSION: Cic inhibits the phagocytic activity of neutrophils in renal transplant patients.
出处
《中国药理学报》
CSCD
1998年第4期372-375,共4页
Acta Pharmacologica Sinica
关键词
肾移植
化学发光
环孢素
嗜中性白细胞
kidney transplantation
chemiluminescence
cyclosporine
neutrophils
peritoneal macrophages
