摘要
目的：观察美施康定（硫酸吗啡控释片）对重度癌痛的镇痛效果，方法：自１９９５年１月至１９９７年４月，将１００例重度癌痛患者随机分为Ａ、Ｂ两组，Ａ组：口服美施康定，每次３０ｍｇ，每日２次，Ｂ组：肌注度冷丁，每次１００ｍｇ，每日２次。结果：镇痛显著有效率，Ａ组为８６％，高于Ｂ组（６６％），Ｐ＜０．０１；镇痛平均维持时间（Ｘ±Ｓ），Ａ组（４．３±１．１小时）长于Ｂ组（３．０±１．４小时），Ｐ＜０．０１。Ａ组副作用主要为恶心、呕吐、便秘等，无精神依赖。结果显示：美施康定控制重度癌痛，具有镇痛效果好，镇痛作用时间长，副作用少，应用方便等优点。
In order to evaluate the analgesia effect of MS CONTIN (Morphine Sulfate Modified release Tablets) to severe cancer pain, 100 patients suffering severe cancer pain were recruited and divided into group A and B at random. Patients in group A were given MS CONTIN p.o., 30mg, bid; Patients in group B were given Dolantine, i.m., 100mg bid. The significant effective rate was 86% in group A and 66% in group B respectively (P<0.01, χ 2 test). The average analgesia duration ( x ±S) was 4.3±1.1h in group A and 3.0±1.4h in group B respectively (P<0.01,t test). Nausea and constipation were the main side effects but no psychological dependence was found in group A. We suggest that MS CONTIN is a more effective analgesic than Dolantin for severe cancer pain with longer lasting duration and less side effects. It can be used as first choice drug for severe cancer pain.
出处
《中国疼痛医学杂志》
CAS
CSCD
1998年第2期82-84,共3页
Chinese Journal of Pain Medicine
关键词
美施康定
镇痛剂
癌痛
MS CONTIN(Morphine sulfate modified release tablets)
Analgesic
Cancer pain
