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基质金属蛋白酶与动脉内膜损伤后再狭窄的研究

Matrix metalloproteinases and the restenosis after injury of arterial intima
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摘要 基质金属蛋白酶是一类蛋白水解酶家族，能降解各种细胞外基质。动物实验和临床病例分析显示基质金属蛋白酶及其抑制剂的平衡对再狭窄的形成至关重要，本文就动脉损伤后基质金属蛋白酶在再狭窄中的作用加以综述。 Matrix metalloproteinases （MMP）are a family of proteolytic enzymes that degrade various components of the extracellular matrix （ECM）. Both animal experiments and clinical sample analysis have shown that balance in expression and activation of MMP and inhibition by tissue inhibitors of matrix metalloproteinase （TIMP）is critical for the development of stenotic change. This review article focuses on the role of MMP relevant to restenosis after vascular injury.
作者 王圣刚 戈小虎
机构地区 石河子大学
出处 《国际外科学杂志》 2009年第6期421-423,共3页 International Journal of Surgery
关键词 基质金属蛋白酶 细胞外基质 血管重塑 再狭窄 matrix metalloproteinases extracellular matrix vascular remodeling restenosis
分类号 R654.3 [医药卫生—外科学]
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参考文献19

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国际外科学杂志
2009年 第6期

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