摘要
目的:从分子水平验证透骨消痛颗粒治疗骨性关节炎疗效,为临床用药提供依据。方法:分子对接法和靶-配体空间分布,初步鉴定出透骨消痛颗粒中治疗骨关节炎疾病的有效成分群。结果:透骨消痛颗粒是通过抑制聚蛋白多糖酶的活性、降低骨内压和降低骨性关节炎细胞因子的产生等起作用,其中,有些化合物显示出多重激酶特性。结论:透骨消痛颗粒对骨性关节炎具有潜在的协同作用。
Objective： To verify the pharmacodynamics of Tougu Xiaotong Granule（TGXTG） in preventing and treating osteoarthritis（OA） in molecular Level, and to provide the basis for clinical application of the medicine. Methods ： Two computational approachs of molecular docking and target-ligand space distribution were oberserved to primarily show the kinds of effective component. Results： The molecules of TGXTG worked to inhibit the activity of aggrecanase , reduce endosteal pressure, decrease the cytokine of osteoarthritis and so on. Some of them showed desired interaction with broader protein targets. Conclusion：TGXTG had potential synergism of OA and the applied value.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2009年第2期98-102,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(No:30672701)
陈可冀中西医结合发展基金(No:CKJ2007004/2007022)
福建省科技厅重点课题(No:2006Y0016)
关键词
透骨消痛颗粒
骨性关节炎
药效学
分子对接法
靶-配体空间分布
协同效应
Tougu Xiaotong Granule （ 透骨消痛颗粒 ）
osteoarthritis
pharmacodynamics
molecular docking
target-ligand space distribu- tion
synergistic effect
