摘要
目的:评估雷帕霉素药物洗脱支架(SES)对糖尿病小型猪冠状动脉支架置入后内膜增生的作用。方法:建立链脲菌素诱导的糖尿病小型猪模型(糖尿病组,n=12),随机选取2支冠状动脉置入SES,共计置入24枚支架,术后饲养6个月,与非糖尿病置入SES支架的小型猪模型(对照组,n=12)比较冠状动脉造影、血管内超声及组织切片检查结果。结果:两组动物支架置入冠状动脉分布,术前参照血管直径[糖尿病组:(2.78±0.35)mm,对照组:(2.81±0.29)mm]及术后即刻最小管腔内径[糖尿病组:(2.90±0.42)mm,对照组:(2.89±0.33)mm]均相似(P均>0.05)。术后6个月糖尿病组支架内狭窄程度[(35.6±9.2)%和(7.9±3.1)%,P<0.001]、支架内晚期管腔丢失[(0.32±0.09)mm和(0.09±0.04)mm,P<0.001]、新生内膜厚度[血管内超声:(0.35±0.12)mm和(0.11±0.08)mm,P<0.05]及新生内膜面积[血管内超声:(1.29±0.51)mm2和(0.26±0.11)mm2,P<0.001;组织切片:(1.24±0.76)mm2和(0.19±0.08)mm2,P<0.05]均显著高于对照组。结论:糖尿病小型猪冠状动脉置入SES后内膜增生程度显著高于无糖尿病模型。
Objective ： To investigate the effect of rapamycin eluting coronary stent for inhibition of neointimal hyperplasia in diabetic porcine model. Methods ：There were two groups in this study. Diabetic group, n = 12, diabetic porcine model was established by a single dose of streptozotocin, and rapamycin eluting coronary stents were randomly implanted into ：2 of the major epicardial coronary arteries. Control group, n=1：2, with non - diabetic porcine. The degree of neointimal hyperplasia evaluated by coronary angiography, intravascular ultrasound （IVUS） and histopathology were compared between two groups respectively at 6 months of the event. Results ：The distribution of vessels received stents, reference vessel diameters and post-procedural minimal luminal diameter were comparable between two groups. All animals received angiographic follow-up at 6 months of time. In Diabetic group, the degreeofstentstenosis （35.6% ±9.2% vs. 7.9% ±3. 1%,P〈0.001）, late lumen loss （0.32 ±0.09 mm vs. 0.09 ±0.04 mm,P 〈0. 001 ）, the thickness of neointima by IVUS examination （0. 35 ±0. 12 mm vs. 0. 11 ±0. 08 mm,P 〈0. 05） and area stenosis by IVUS （ 1.29 ±0. 51 mm^2 vs. 0. 26 ±0. 11 mm^2 , P 〈0. 001 ） ; and histopathological examination （ 1.24 ±0. 76 mm^2 vs. 0. 19 ±0. 08mm^2, P 〈0. 05 ） were significantly higher than those in Control group. Conclusion： The neointimal hyperplasia after rapamycin eluting stent implantation was significantly severe in the diabetic porcine models than those in non -diabetic ones.
出处
《中国循环杂志》
CSCD
北大核心
2009年第3期185-188,共4页
Chinese Circulation Journal
基金
上海市科委重大课题(04JC14046)
