摘要
目的了解北京老年医院肺结核病人耐药状况。方法将2002年8月—2008年8月4195例肺结核患者中,对痰培养阳性1125例的结核病人的4种抗结核药物和左氧氟沙星耐药测试的资料进行分析。结果1.耐药病人566例,占50.3%。MDR-TB病人135例,MDR-TB率为12.0%。2.年龄分布以老年为主。3.对任一药累计耐药顺序为S>H>R>E。4.对左氧氟沙星低浓度耐药为32.5%,高浓度为9.0%。结论本院肺结核病例耐药率和耐多药率尚较高,需进一步分析原因,对左氧氟沙星已有一定程度效果,将对MDR-TB的治疗带来影响。
Objective To understand the distribution and influential factors of patients with drug resistance among TB patients in our hospital. Methods 1 125 patients with sputum culture positive from 4 195 patients with pulmonary tuberculosis from Aug. 2002 to Aug. 2008 were divided into initial drug resistance group, acquired drug resistance group, drug resistance group, and multi- drug resistance group according to different standards. The data of resistant test of four anti-TB drug for these patients was analyzed with clinical epidemiology method. Results 1.There were 566（50.3%） cases in the drug resistance group and 135（12.0%） cases in the MDR-TB group（X^2= 13. 457, P〈0.05） with statistically significant difference in resistance rate of the two groups. 2. Age distribution is mainly the elderly, 3. Of any drug, the order of accumulated drug resistance is S〉H〉R〉E. 4. High concentration of levofloxacin resistance is 32.5%, and low concentration is 9.0%. Conclusions The drug-resistance rate and multi-drug resistance tate aftuberculosis is still high, further analysis is needed. The rate of drug resistance of high concentration of Levofloxa-cin is low, which would have deep effect on the therapy of MDR-TB.
出处
《中国防痨杂志》
CAS
2009年第6期331-333,共3页
Chinese Journal of Antituberculosis
关键词
结核
肺/药物疗法
抗药性
细菌
北京市
pulmonary tuberculosis/drug therapy
drug resistance, bacterial
Beijing city
