期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乙型肝炎病毒基因变异及其临床意义 被引量：6

Hepatitis B virus variation and its clinical significance
原文传递
导出
摘要 乙型肝炎病毒(hepatitis B vius,HBV)感染是导致慢性乙型肝炎(chronic hepatitis B,CHB)、肝硬化(liver cirrhosis,LC)和肝细胞癌(hepatocellular carcinoma,HCC)的重要原因,全球每年由于HBV慢性感染引起的肝硬化、肝细胞癌死亡患者超过47万人。本文主要对乙肝病毒的相关变异及与临床治疗和预后的关系作一介绍。 Hepatitis B virus infection is the major cause of chronic hepatitis B （CHB）, liver cirrhosis （LC）, and hepatocellular carcinoma （HCC）. Over 47 000 people die of LC and HCC caused by HBV infection in the world each year. This article introduces the related variations of hepatitis B virus and the correlation with clinical treatment and prognosis.
作者 谢佳新 殷建华 何永超 曹广文
机构地区 第二军医大学卫生勤务学系流行病学教研室
出处 《中华疾病控制杂志》 CAS 2009年第3期358-361,共4页 Chinese Journal of Disease Control & Prevention
基金 上海市优秀学科带头人计划(A类)(08XD14001)
关键词 肝炎病毒 乙型 变异 基因型 Hepatitis B vius Variation Genotype
分类号 R373.21 [医药卫生—病原生物学] R512.62 [医药卫生—内科学]
  • 相关文献

参考文献22

  • 1Tanaka Y, Mukaide M, Orito E, et al. Specific mutations in enhancer Ⅱ/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma [ J ]. J Hepatol, 2006,45 (5) : 646-653.
  • 2Chu CM, Yeh CT, Lee CS, et al. Precore stop mutation HBeAg positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion [J]. J Clin Micrnhiol , 2002,40(1):16-21.
  • 3谢琴秀,许家璋,李平,杨志国,孟运运,李旭.江苏地区乙型肝炎病毒基因分型及其临床意义[J].疾病控制杂志,2005,9(2):171-173. 被引量：42
  • 4Truong BX, Seo Y, Yano Y, et al. Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam [J]. Int J Mol Med, 2007,19(2) :293-299.
  • 5Tong MJ, Blatt LB, Kao JH, et al. Basal core promoter T1762/ A1764 and precore A1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: a comparison with chronic carriers [J]. Liver Int, 2007,27(10) :1356-1363.
  • 6Yoo BC, Park JW, Kim HJ, et al. Precore and core promoter mutations of hepatitis B virus and hepatitis B e antigen-negative chronic hepatitis B in Korea [ J ]. J Hepatol, 2003,38 ( 1 ) : 98- 103.
  • 7Yuan J, Zhou BP, Tanaka Y, et al. Hepatitis B virus (HBV) genotypes/subgenotypes in China: mutations in core promoter and precore/core and their clinical implications [ J ]. J Clin Virol, 2007.39 (2) : 87-93.
  • 8Wu L, He JW, Yao X, et al. A novel hepatitis B virus variant S 129 (Gin-> Leu): lack of correlation between antigenicity and immunogenicity [J]. J ivied Virol , 1999,59(4):424-430.
  • 9Cao Z, Bai X, Guo X, et al. High prevalence of hepatitis B virus pre-S mutation and its association with hepatocetlular carcinoma in Qidong, China [J]. Arch Virol, 2008,153(10) : 1807-1812.
  • 10Chen BF, Liu CJ, Jow GM, et al. High Prevalence and Mapping of Pre-S Deletion in Hepatitis B Virus Carriers With Progressive Liver Diseases [J]. Gastroenterology, 2006, 130(4): 1153-1168.

二级参考文献7

  • 1Kao JH, Chen PJ, Lai MY, et al . Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B Gastroentemlogy, 2000,118 ( 3 ) : 554-559.
  • 2Kao JH, Chen PJ, Lai MY, et al . Clinical and virological aspects of blood donors infected with hepatitis B virus genotypes B and C[J]. J Clin Microbiol , 2002,40(1 ) :22-25.
  • 3Sakugawa H, Nak&sone H, Nakayoshi T, et al . Preponderance of hepatitis B virus genotype B contributes to better prognosis of chronic HBV infection in Okinawa [J]. Japan y Med Virol ,2002,67 ( 4 ) : 484-489.
  • 4Norder H, Courouce AM, Magnius LO, et al. Complete genomes, phylogenetic relatedness and structural proteins of six strains of the hepatitis B virus, four of which represent two newgenotypes [J]. Virology , 1994,198(2):489-503.
  • 5中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量：14012
  • 6夏国良,Omana V Nainan,贾志远,刘洪斌,罗述斌,李荣成,曹慧霖,刘崇柏,HaroldS Margolis.乙型肝炎病毒基因型和血清亚型在我国部分地区的分布及其特点[J].中华流行病学杂志,2001,22(5):348-351. 被引量：131
  • 7葛宪民,李丹亚,方钟燎,黄果勇,江世强,潘海东,杜岩,王超英,丁欣,沟上雅史.广西乙型肝炎病毒基因分型及其临床意义的研究[J].中华实验和临床病毒学杂志,2003,17(2):174-179. 被引量：41

共引文献41

同被引文献41

引证文献6

二级引证文献9

中华疾病控制杂志
2009年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部