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Biginelli 3,4-二氢嘧啶-2-酮衍生物的合成研究新进展 被引量：15

New Advances in the Synthesis of Biginelli 3,4-Dihydropyrimidin-2(1H)-one Derivatives
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摘要 1893年,意大利化学家Biginelli首次利用芳香醛、乙酰乙酸乙酯和尿素三组分"一锅煮法"合成了3,4-二氢嘧啶-2(1H)-酮.此类化合物具有良好的生物活性和反应活性,对近几年来有关Biginelli 3,4-二氢嘧啶-2(1H)-酮的衍生化反应、Biginelli不对称合成和Biginelli反应在天然产物合成中的应用研究进行了综述. In 1893, Biginelli reported the first synthesis of 3,4-dihydropyrimidin-2（1H）-ones （DHPM） by a very simple one-pot condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate. It has been established that Biginelli-type dihydropyrimidinones present interesting pharmacological properties assiociated with good reactivities. In this article, the recent developments in the synthesis of DHPM derivatives, asymmetric Biginelli compounds and natural products using Biginelli reaction have been reviewed.
作者 权正军 张彰 达玉霞 王喜存
机构地区 西北师范大学化学化工学院甘肃省高分子材料重点实验室
出处 《有机化学》 SCIE CAS CSCD 北大核心 2009年第6期876-883,共8页 Chinese Journal of Organic Chemistry
基金 甘肃省自然基金(No.3ZS061-A25-019) 甘肃省教育厅(No.0601-25)资助项目
关键词 Biginelli缩合反应 3 4-二氢嘧啶-2(1H)-酮 不对称合成 天然产物合成 Biginelli condensation reaction 3,4-dihydropyrimidin-2（1H）-one asymmetric synthesis natural product synthesis
分类号 TQ463.5 [化学工程—制药化工]
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参考文献61

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二级参考文献44

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有机化学
2009年 第6期

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