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骨髓间充质干细胞向肝(样)细胞的分化及其在肝脏疾病的应用

Differentiation of bone marrow-derived mesenchymal stem cells in liver and its application in liver diseases
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摘要 骨髓间充质干细胞在肝脏病理条件或体外诱导分化为有功能的肝(样)细胞以及对受损肝脏的修复作用是目前研究的热点。本文就骨髓间充质干细胞分化潜能及其可能的机制、免疫学特性以及在肝脏疾病的应用研究作系统的综述。 Presently, it was the research hotspot that bone marrow-derived mesenchymal stem cells （BM- MSCs） had the ability to differentiate into functional hepatoeytes or hepatocyte-like cells in vitro through induction or in some pathologic environments as well as restore the injured livers by cell transplantation. This review focused on the differentiation potential of BM-MSCs and its possible mechanism, immunological characteristics, as well as the application of BM-MSCs in liver diseases.
作者 黄育波 林炳亮
机构地区 中山大学附属第三医院感染科
出处 《国际内科学杂志》 CAS 2009年第6期370-372,F0003,共4页 International Journal of Internal Medicine
关键词 骨髓间充质干细胞 肝细胞/肝样细胞 分化 肝脏疾病 Bone marrow-derived mesenchymal stem cells Hepatocyte/Hepatocyte-like cells Differentiation Liver disease
分类号 R575 [医药卫生—消化系统]
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参考文献28

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二级参考文献20

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共引文献44

国际内科学杂志
2009年 第6期

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