摘要
采用叔丁氧羰基(Boc)、苄氧羰基(Z)和芴甲氧羰基(Fmoc)这3种保护基保护苯丙氨酸的氨基,顺利得到3个保护的苯丙氨酸(Ⅲa-c);保护的苯丙氨酸与精左氨基物(Ⅱ)进行偶联,较高收率地合成了3个未见文献报道的目标分子(Ⅳa-c),产物的结构通过IR,1H NMR,13C NMR测试得到了验证.对氨基酸的保护及偶联反应的条件进行了优化.
With butyloxycarbonyl （Boc）, benzyloxycarbonyl （Z） and fluorenylmethyloxycarbonyl （Fmoc） as protecting groups, three amino group-protected L-phenylalanines were successfully obtained. Aided by different coupling reagents, three new conjugated products of the amino group-protected L-phenylalanines with chloramphenicol base were synthesized with a yield of 70%- 78%. The chemical structures of the new compounds were confirmed by IR, 1H NMR, and 13C NMR. The conditions for the reactions mentioned above were optimized.
出处
《西南大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第6期184-188,共5页
Journal of Southwest University(Natural Science Edition)
基金
重庆市自然科学基金资助项目(2005BB5095)
西南师范大学博士科研基金资助项目(SWNU.B2005010)
西南师范大学高新技术培育基金资助项目(XSGX05)
关键词
L-苯丙氨酸
精左氨基物
氨基保护
偶联反应
L-phenylalanine chloramphenicol base amino group protection coupling reaction
