摘要
目的:采用综合超声心动图多项参数的心衰超声指数评价慢性心力衰竭患者的心功能状态,旨在为临床提供更为全面、客观和量化的指标。方法:前瞻性研究慢性心力衰竭患者116例(心衰组),正常者24例(对照组),所有入选者进行心衰超声指数的评分,并将该评分与同期血浆氨基末端脑钠肽前体(NT-ProBNP)水平及纽约心功能分级(NYHA)进行比较,同时评价其诊断慢性心力衰竭的敏感性与特异性。结果:(1)心衰超声指数值在心衰组明显大于对照组,当心衰超声指数值大于≥3时,其诊断慢性有症状性心力衰竭的敏感性、特异性、阳性预测值、阴性预测值分别为88.6%、91.4%、96.8%及80.0%。(2)相关性分析表明心衰超声指数值与LogNT-ProBNP水平呈明显正相关(r=0.86,P<0.01)。(3)NYHAⅠ、Ⅱ、Ⅲ、Ⅳ级患者的心衰超声指数值分别为1.80±0.80、3.66±1.49、4.96±2.09和6.07±1.78,方差分析显示组间差异均有显著性(P<0.01)。结论:应用心衰超声指数来诊断慢性心衰及客观评价其严重程度是可行的,心衰超声指数作为综合评价慢性心衰患者心功能状态的一个新指标值得在临床推广应用。
Objective Heart failure echocardiography index （HFEI）, which had synthesized multinomial parameters of echocardiography, was used to evaluate the cardiac function of patients with chronic heart failure （CHF） for the purpose of providing an objective, comprehensive, and quantitative criterion for appraising CHF. Methods HFEI in 116 patients with CHF （CHF group） and 24 normal controls （control group） were evaluated and compared with the levels of contemporaneous NT-ProBNP and the NYHA class, and the sensitivity and specificity of HFEI for CHF diagnosis were appraised. Results HFEI in CHF group was significantly higher than that in control group （P 〈 0.01）. When the eutoff point of HFEI was set to be 3, the sensitivity, specificity, positive predictive value, and negative predictive value of HFEI for diagnosing CHF were 88.6%, 91.4%, 96.8%, and 80.0%. There was a remarkable positive correlation between HFEI and Log NT-ProBNP （r = 0.86, P 〈 0.01）. There were significant differences of HFEI among NYHA class Ⅰ ,Ⅱ , Ⅲ ,and Ⅳ（1.80 ± 0.80, 3.66 ±1.49, 4.96 ± 2.09, 6.07 ± 1.78, P 〈 0.01）. Conclusion HFEI can be used to diagnose CHF and evaluate the degree of it, and is worth generalizing.
出处
《实用医学杂志》
CAS
北大核心
2009年第12期1972-1974,共3页
The Journal of Practical Medicine
