摘要
[目的]观察不同剂量敌敌畏染毒后不同时点大鼠心血管功能指标的变化。[方法]复制敌敌畏急性中毒SD大鼠动物模型(15mg/kg、25mg/kg),另设生理盐水对照组(0mg/kg)。采用股动脉和左心室插管的方法,观察染毒前及染毒后15、30、45、60、75、90min时大鼠收缩压、舒张压、心率、最高左心室内压和左心室内压最大上升速率等指标的变化。[结果]15、25mg/kg敌敌畏染毒后不同时点的大鼠心率有所下降;染毒90min后分别降为染毒前的78%和77%(P<0.05);收缩压降为染毒前的89%和91%(P<0.05);左心室内压最大上升速率低于染毒前(P<0.01)。与对照组比较,15、25mg/kg组在同一时点的收缩压、舒张压、心率、最高左心室内压、左心室内压最大上升速率的改变均有统计学意义(P<0.05或P<0.01)。[结论]不同剂量敌敌畏可以不同程度地抑制大鼠心血管功能,左心室内压最大上升速率改变较为明显。
[ Objective ] To study the acute effects of dichlorvos on cardiovascular functions in rats. [ Methods ] Femoral artery and ventricle cannulation was performed prior to dichlorvos treatments for monitoring of physiological indications including systolic pressure, diastolic pressure, heart rate, peak left intraventricular pressure, and the maximum rate of rise of left ventricular pressure. Male Spraque Dawley rats were treated by intravenous injection with dichlorvos at the doses of 0（ saline control ）, 15, and 25 mg/kg. The parameters mentioned above were recorded at 0, 15, 30, 45, 60, 75, and 90 minutes after treatment. [ Results ] There was a decrease in heart rate in 15 mg/kg and 25 mg/kg dose groups at different time points, and at the end of the study the heart rates decreased to 78 and 77 percent, respectively, of the pre-administration level （ P 〈 0.05 ）. Systolic pressure decreased to 89 and 91 percent of the pre-administration level （ P 〈 0.05 ）. The values of the maximum rate of rise of left ventricular pressure in 25 mg/kg group were significantly lowered at 90 min comparing to the pre-adminstrative level. Lateral comparison between the control group and dichlorvos treated groups at the same time points gave significant difference in systolic pressure, diastolic pressure, heart rate, peak left intraventricular pressure, and the maximum rate of rise of left ventricular pressure. Cardiovascular damages caused by the higher dose were more extended in time. [ Conclusion ] Dichlorvos can cause damages in the cardiovascular system, and the degree of damage correlates to dose. Among the parameters monitored, change in the maximum rate of rise of left ventricular pressure was more severe.
出处
《环境与职业医学》
CAS
北大核心
2009年第3期248-251,共4页
Journal of Environmental and Occupational Medicine
基金
国家科技支撑计划(编号:2006ABI06B01)
关键词
敌敌畏
心血管功能
血压
心率
dichlorvos
cardiovascular function
blood pressure
heart rate
