摘要
长期以来组织工程研究主要手段是原代细胞分离和培养(种子细胞),将细胞种植到支架材料上,在体外静态或动态(生物反应器)培养这种细胞/支架复合物,最后进行体内移植实验或应用。多年来的研究表明,这种手段依赖于自体细胞,耗时,费用昂贵,组织工程产品的生物功能不理想,而且很难实现临床推广应用。近几年生物材料科学家提出了组织诱导性生物材料的新概念。基于对材料的微观孔结构设计、化学修饰和复合生物活性分子,赋予材料诱导组织再生的活性,使组织再生和修复在体内完成。由此产生"体内组织工程"和"组织诱导性生物材料"等概念。这正在成为组织工程研究的发展方向。本文在调研最近三年相关论文的基础上,对组织诱导性材料的研究进展进行了简要综述。
Tissue engineering has typically been such an approach that relies on isolation and culture of primary cells （seed cells）, seeding these cells onto porous scaffolds, maintaining under static or flow condition （Bioreactor） for a period of time prior to implantation. However, experience of almost thirty years in this research field tells us that the typical tissue engineering approach relies on autologous cells, expensive and time consuming. Tissue engi- neering products do not function very well and are difficult to get FDA approval. In recent years biomaterial scientists created a new concept ＂Tissue Inducible Biomaterials＂. The concept is based on designing of mierostructure of scaffolds, chemical modification and incorporation of bioactive molecule to scaffolds. Thus the scaffolds gain tissue induction activity, and will facilitate tissue regeneration and repair in vivo. The concepts of ＂In Vivo Tissue Engineering＂ and ＂Tissue Inducible Biomaterials＂ are been recognized by the Society, and are becoming the new approaches in tissue engineering. Based on the research of the related references within the past three years, the present paper summarized the strategy of tissue inducible biomaterials.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2009年第3期461-464,共4页
Journal of Biomedical Engineering
关键词
组织诱导性生物材料
组织工程
体内组织工程
生物材料
再生医学
Tissue inducible biomaterials Tissue engineering In vivo tissue engineering Biomaterials Regenerative medicine
