摘要
目的探讨血清肝细胞生长因子(HGF)在2型DM不同肾损害期中的变化、临床意义及糖尿病肾病发生发展中的作用。方法将2型DM患者92例分为不同的组别,其中尿白蛋白正常组30例,尿白蛋白微量组32例,尿白蛋白明显增高组30例;糖耐量异常患者33例,采用ELISA法检测血清HGF水平,同时用化学发光法检测尿微量白蛋白。结果糖耐量异常组和尿白蛋白正常组HGF浓度明显高于对照组(P<0.05);尿白蛋白微量组及尿白蛋白明显增高组HGF浓度明显低于对照组(P<0.05);且尿白蛋白明显增高组又显著低于尿白蛋白微量组(P<0.05)。结论2型DM患者不同肾损害期HGF浓度差别有统计学意义,检测血HGF水平可为糖尿病肾病的诊断和治疗监测提供可靠依据。
Objective To study the changes and chnical significance of serum hepatocyte growth factor （HGF） in different period of kidney damage in type 2 diabetic patients. Methods There 92 type 2 diabetic patients were divided into three groups including the normal albuminuria group （Group A） consisted of 30 cases,a little over normal albuminuria group consisted of 32 patients （Group.B）and a high albuminuria group consisted of 30 case （Group C）. Another 33 glucose resistent patients were respectively collected,and serum HGF levels were tested with ELISA,the urine in 24 hours was collected for detection of urinary micro-albumin. Results HGF concentrations in glucose resistence in Group A and Group B were significandy higher than that of control group （P〈0. 05）,HGF concentrations in large more than normal albuminuria group is significantly lower than that in micro-albuminuria group（P〈0. 05）. Conclusion There is statistical significance of HGF concentrations in different kidney damage stages of type 2 diabetic, and serum levels of HGF can provide a dependable theoretical basis for diagnosis and treatment-monitoring of diabetic nephropathy.
出处
《中国热带医学》
CAS
2009年第7期1192-1193,共2页
China Tropical Medicine
关键词
肝细胞生长因子
尿白蛋白
糖尿病肾病
Hepatocyte growth factor（HGF）
Urinary albuminuria
Diabetic nephmpathy
