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低分子肝素治疗脑缺血发作近远期疗效观察

Efficacy of low molecular heparin on transient ischemic attacks
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摘要 目的观察低分子肝素治疗频发短暂性脑缺血发作(TIA)的近远期疗效。方法63例频发TIA患者随机分为低分子肝素组(治疗组)30例和常规治疗组(对照组)33例。观察两组TIA发作停止时间;治疗前及治疗后7d血小板计数(Plt)、出血时间(BT)、凝血时间(CT)、凝血酶原时间(PT)、纤维蛋白原定量(Fib),出院后3个月、6个月TIA发作次数,住院期间、出院后3个月、6个月进展为脑卒中例数。结果24h内及48h内TIA发作控制率治疗组分别为36.7%、70%,对照组分别为12.1%、33.3%,两组比较有统计学差异(χ2=3.15,P<0.05)。随访3个月、6个月治疗组TIA发生率分别为13.3%、23.3%、脑梗死发生率分别为0、3.0%,对照组TIA发生率分别为27.3%、33.1%、脑梗死发生率分别为12.1%、21.2%,两组比较无统计学差异(P>0.05)。治疗组治疗后Fib明显降低,与治疗前比较用统计学差异P<0.05)。两组治疗前后BT、CT、PT无显著性差异。结论低分子肝素治疗频发短暂性脑缺血发作近期疗效显著、安全。
机构地区 海南省人民医院
出处 《中国热带医学》 CAS 2009年第7期1262-1263,共2页 China Tropical Medicine
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