摘要
目的:研究稀有抗肿瘤人参皂苷衍生物的制备与分离。方法:采用硅胶柱层析等色谱方法对人参总皂苷酸解产物进行分离,并通过重结晶纯化、理化常数测定和波谱数据进行化合物的结构鉴定。结果:从人参总皂苷酸水解产物中分离得到11个化合物,鉴定出10个化合物的化学结构分别为达玛烷-20(22)-烯-3β,12β,26-三醇(Ⅰ)、20(S)-25-甲氧基-达玛烷-3β,12β,20-三醇(Ⅱ)、人参二醇(Ⅲ)、20(S)-原人参二醇(Ⅳ)、20(R)-原人参二醇(Ⅴ)、20(S)-人参三醇(Ⅵ)、拟人参皂苷-F11苷元(Ⅶ)、20(R)-原人参三醇(Ⅷ)、20(R)-达玛烷-3β,12β,20,25-四醇(Ⅸ)、20(R)-25-羟基原人参五醇(Ⅹ)。结论:化合物Ⅰ、Ⅱ为从西洋参(茎、叶、果、花蕾)中首次发现。化合物Ⅸ为本课题组首次发现和报道的具有显著抗肿瘤活性的原人参二醇型皂苷元衍生物。
Objective ： To prepare and isolate the rare ginsenoside derivatives of anti-cancer activity. Methods ： Acid-degradation products of ginsenosides were isolated and purified by various chromatographic techniques such as silica gel and so on; compounds were identified and elucidated by spectral and chemical methods. Results： Eleven compounds were obtained from the products of Acid-degradation. Conclusion ： Compound Ⅰ , H are discoverd from the roots, stems, leaves, fruits and alabastrums of Panax quinquefolium L for the first time. Compound Ⅸ of derivate of the aglycone of protopanoxadiol ginsenoside was discovered and reported, having the conspicuous anti-cancer activity for the first time from the fruits of Panax ginseng.
出处
《中药材》
CAS
CSCD
北大核心
2009年第5期707-709,共3页
Journal of Chinese Medicinal Materials
关键词
人参皂苷
酸水解
稀有抗肿瘤人参皂苷元
Ginsenosides
Acid-degradation products
Rare ginsenoside derivatives of anti-cancer activity
