摘要
目的观察中西医结合疗法治疗原发性肾病综合征(PNS)的临床疗效。方法将248例PNS患者随机分为2组。对照组124例予常规西医治疗,治疗组124例在对照组治疗基础上加用黄芪当归合剂合当归芍药散加减,每日1剂,水煎分2次服。2组均1个月为1个疗程,6个疗程后观察临床疗效,24h尿蛋白定量、血清白蛋白、血脂、肾功能及尿纤维蛋白降解产物(FDP),副作用和并发症及复发情况。结果治疗组治疗后24h尿蛋白定量、血清白蛋白、胆固醇、肌酐及尿FDP与本组治疗前比较差异均有统计学意义(P<0.05,P<0.01);治疗组副作用和并发症发生率(19.4%)低于对照组(61.3%)(P<0.01);治疗组复发率4.0%,完全缓解率64.5%,对照组复发率11.3%,完全缓解率23.4%,2组比较差异均有统计学意义(P<0.01)。结论益气活血利水法配合常规西医治疗原发性肾病综合征疗效确切。
Objective To investigate the clinical effect of combination of traditional Chinese medicine and western medicine on the treatment of primary nephrotic syndrome （PNS）. Methods 248 patients with PNS were di- vided randomly into two groups. The patients in treatment group （ n = 124） were treated by combination of traditional Chinese medicine and western medicine. Patients in control group （ n = 124） were treated by routine western medi- cine. The course was a month in both groups. The effect was evaluated by observing changes of 24h quantitative of urinary protein, plasma albumin, blood -fat, renal function, FDP and recurrence in two groups before and after treat- ment. Results There were obvious abnormality in biochemical indicators and FDP before treatment in two groups （ P 〈 0. 01 or 〈 O. 05）. The total effective rate in treatment group （96.0 % ） was higher than that in control group （75.8 %, P 〈0.05 ）. The incidence rate of side- effects and complication in control group （61.3%） was higher than that in treatment group （19.4%）. The recurrent rate in treatment group was lower （4.0%） than that in control group （ 11.3% ）. Conclusion Combination of traditional Chinese medicine and western medicine was effective on the treatment of primary nephrotic syndrome.
出处
《河北中医》
2009年第5期707-709,共3页
Hebei Journal of Traditional Chinese Medicine
关键词
肾病综合征
中西医结合疗法
Integrated traditional Chinese and western medicine therapy
Nephrotic syndrome
