摘要
目的探讨利培酮与喹硫平对伴精神行为症状的老年期痴呆患者(BPSD)的体重、血糖及血脂的影响。方法将60例伴精神行为症状的老年期痴呆患者分为喹硫平组及利培酮组进行治疗,于治疗前及治疗后(第4、8周末)分别测体重、空腹血糖及血脂包括胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白(LDL)及高密度脂蛋白(HDL)。结果喹硫平组的体重及LDL在治疗第8周末较治疗前升高,HDL较治疗前下降,差异具有显著性(P<0.05)。利培酮组治疗前后各数值的变化无显著差异(P>0.05)。两组患者体重的第8周末与治疗前差值,LDL的第8周末与第4周末的差值比较有统计学意义(P<0.05)。结论喹硫平对伴精神行为症状的痴呆患者体重、血脂的影响较利培酮明显,两者对糖代谢影响不大。
Objective To assess the effects of quetiapine and risperidone on the blood glucose , body weight and lipid levels in elderly patients with dementia. Methods A total of 60 patients with senile dementia were randomly divided into quetiapine group and risperidone group. Planed assessments included blood glucose,total cholestrol （TC）, triglycerides （TG）, high density lipoprotein- cholesterol（HDL）,Iow density lipoprotein-cholesterol （LDL） and the body weight,which were collected at baseline ,the end of 4th and 8th week after treatment. Results After 8-week treatment,the levels of body weight and LDL were significanlty higher and the levels of HDL were lower than those before treatment in quetiapine group （P〈 0.05）. Quetiapine group showed significantly larger changes of body weight and LDL at the end of the treatment than risperidone group （P〈 0. 05）. Conclusion Quetiapine has more effects on the body weight and lipid levels than risperidone in patients with senile dementia.
出处
《精神医学杂志》
2009年第3期167-169,共3页
Journal of Psychiatry
关键词
喹硫平
利培酮
体重
血糖
血脂
痴呆
Quetiapine Risperidone Body weight Blood glucose Blood lipid Dementia
