摘要
目的:观察盐酸戊乙奎醚对体外循环冠状动脉旁路移植术患者血浆炎性因子的影响。方法:选择择期体外循环下冠状动脉旁路移植术患者40例,随机分为盐酸戊乙奎醚组20例(A组)和对照组20例(B组)。A组于体外循环前10min静脉注射盐酸戊乙奎醚3mg,对照组给予等量生理盐水。测定血浆肿瘤坏死因子-α、白细胞介素-6、和白细胞介素-10浓度。结果:组内比较B组肿瘤坏死因子-α浓度于体外循环后3h高于麻醉诱导前(P<0.01),而A组体外循环30min、主动脉开放后l0min肿瘤坏死因子-α浓度较麻醉诱导前明显降低,其余时点与术前比较无明显变化。B组白细胞介素-6于体外循环后24h高于A组(P<0.05),白细胞介素-10浓度明显低于A组。2组间比较,B组坏死因子-α浓度于体外循环30min,24h各时点均高于A组(P<0.05)。结论:盐酸戊乙奎醚可部分抑制体外循环导致的炎性反应,对体外循环术后全身炎性反应综合征有一定的预防作用。
Objective To observe the effects of penehyclidine hydrochloride on the inflammatory factors during extracorporeal circulation in patients with coronary artery bypass grafting. Methods Forty patients were randomly divided into group A and B, 20 patients each. Group A was given 3 mg penehyclidine 10 minutes before extracorporeal circulation. Group B received saline solution as placebo. Tumor necrosis factor-a, IL-6 and IL-10 were measured with radioimmunity in all patients. Results In group B, IL-6 level was higher 3 hours after extracorporeal circulation than before anesthesia（P〈0.01）. In group A, tumor necrosis factor-a level was significantly higher 30 minutes after extracorporeal circulation and 10 minutes after aorta opening than before anesthesia. IL 6 level was higher 24 hours after extracorporeal circulation in group B than in group A（P〈0.05）, and IL 10 was lower. TNF-a level was also higher in control B than in group A （P 〈 0. 05）. Conclusion Penehyclidine hydrochloride could partially inhibit extracorporeal circulation-related whole body inflammatory response by intraoperative administration, and maybe helpful in preventing the systemic inflammatory response syndrome.
出处
《中华实用诊断与治疗杂志》
2009年第6期563-565,共3页
Journal of Chinese Practical Diagnosis and Therapy
