摘要
目的:研究复方氨基酸螯合钙(乐力钙)和碳酸钙(钙尔奇D)单剂量口服给药后在健康受试者体内钙的吸收情况,评价复方氨基酸螯合钙的生物利用度。方法:采用原子吸收分光光度法,测定21名健康受试者按照三交叉试验服用氨基酸螯合钙(相当于钙500mg)、碳酸钙(相当于钙600mg)、空白对照后24h尿液中钙浓度,计算药动学参数和生物利用度。结果:在0～24h内,氨基酸螯合钙及碳酸钙的尿钙排泄增量分别为(61.8±32.8)mg、(37.5±29.1)mg;最大排泄率分别为(4.8±2.5)mg·h-1、(3.5±1.5)mg·h-1;达峰时间分别为(3.4±2.6)h、(4.0±4.4)h;尿钙排泄百分率分别为:(10.3%±5.5%)、(6.2%±4.8%);与碳酸钙比较,氨基酸螯合钙的生物利用度为471.0%±630.5%。结论:采用24h尿钙分析方法,复方氨基酸螯合钙的吸收优于碳酸钙。
OBJECTIVE To compare the absorption of calcium from calcium amino acid chelate and calcium carbonate using 24-h urine calcium method conducted in healthy male volunteers. METHODS In a three-way crossover study, either a blank or 600 mg of calcium in the form of calcium carbonate, 500 mg of calcium in calcium amino acid chelate were administered orally to 21 healthy male volunteers who had fasted overnight. Urine calcium was measured afterward. Absorption of the different calcium-supplement regimens was evaluated by changes in 24-h urinary excretion of calcium. After calcium was administered, absorption of the different calcium-supplement regimens was evaluated by changes in calcium ions concentration in 24-h urinary excretion. RESULTS Urine calcium increments, max excretory rate, Tmax and excretory percent for calcium amino acid che late calcium carbonate were（61.8 ± 32. 8）mg vs. （37. 5 ± 29. 1 ）mg, （4. 76 ± 2. 46 ）mg·h^-1 vs. （3.5 ± 1. 5）mg·h^-1 , （ 10. 3% ±5.5%） vs. （6. 2% ± 4. 8%）, （3.4 ± 2.6）h vs. （4. 0 ± 4. 4）h,respectively. Compare with carbonate calcium, bioavailability of calcium amino acid chelate was（471.0% ± 630. 5%）. CONCLUSION Our data indicate that calcium amino acid chelate is superior to calcium carbonate using 24 h urine calcium method, which partly represented calcium absorption. Calcium amino acid chelate may offer significant advantages as a dietary calcium supplement.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第12期983-986,共4页
Chinese Journal of Hospital Pharmacy
基金
辽宁省科学技术厅重大项目资助(编号:2006226006)
关键词
健康志愿者
钙吸收
复方氨基酸螯合钙
碳酸钙
healthy volunteers
calcium absorption
compound calcium amino acid chelate
calcium carbonate
