期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

慢性心力衰竭大鼠心肌神经生长因子表达及卡维地洛治疗的影响 被引量：2

原文传递
导出
摘要 目的评价卡维地洛（Carvedilol）对慢性心力衰竭（CHF）大鼠心肌神经生长因子（NGF）表达的影响方法应用阿霉素腹腔注射的方法制作CHF大鼠模型，根据干预药物的不同分组为特拉唑嗪组（CHF—T）、卡维地洛组（CHF—C）、倍他乐克组（CHF—M）和安慰剂组（CHF—P）；10周后透射电镜评价大鼠心肌超微结构，RT—PCR和Western blot方法分别测定大鼠心肌NGF mRNA和蛋白表达水平。结果CHF—P组NGF mRNA和蛋白表达水平比正常对照组明显下降（P〈0．01）；CHF—C组NGF mRNA和蛋白的表达明显高于CHF—P组（P〈0．05）和CHF—M组（P〈0．05）；CHF—C组NGF mRNA和蛋白表达与CHF—T组差异无统计学意义（P〉0．05）。结论CHF大鼠心肌NGF表达水平明显下调，卡维地洛治疗能够阻止CHF心肌NGF下调，有助于改善CHF大鼠心肌交感神经重构。
作者 李书国 杨俊 丁家望 吴辉 陈勇 李莉 吕志阳 姜玉蓉
机构地区 三峡大学第一临床医学院心内科
出处 《中国医师杂志》 CAS 2009年第6期846-849,共4页 Journal of Chinese Physician
关键词 丙醇胺类/药理学 心力衰竭 充血性/遗传学/药物疗法 神经生长因子类/生物合成/药物作用
分类号 R541.6 [医药卫生—心血管疾病] R651.3 [医药卫生—外科学]
  • 相关文献

参考文献8

  • 1Colucci WS. The effects of norepinephrine on myocardial biology : implications for the therapy of heart failure. Clin Cardiol, 1998,21 : 120-124.
  • 2Himura Y, Felten SY, Kashiki M, et al. Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure. Circulation, 1993, 88:1299-1309.
  • 3Poole-Wilson PA, Swedberg K, Cleland JG, et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial ( COMET) : randomised controlled trial. Lancet,2003,362: 7-13.
  • 4Riekli H, Steiner S, MOiler K,et al. Betabloekers in heart failure: Carvedilol Safety Assessment ( CASA 2-trial). The European Journal of Heart Failure,2004, 6:761-768.
  • 5李书国,毛小波,张峰,孙正雄,曾秋棠.阿霉素诱导慢性充血性心力衰竭模型制作的改良方案[J].中国比较医学杂志,2006,16(7):415-418. 被引量：18
  • 6Kinugawa T, Ogino K, Osaki S, et al. Prognostic signiticance of exercise plasma noradrenaline levels for cardiac death in patients with mild heart failure. Circ J,2002,66 ( 3 ) :261-266.
  • 7Glebova NO, Ginty DD. Heterogeneous Requirement of NGF for Sympathetic Target Innervation In Vivo. The Journal of Neuroscience, 2004,24 : 743 -751.
  • 8Lockhart ST, Turrigiano GG, Birren SJ, et al. Nerve growth factor mod- ulates synaptic transmission between sympathetic neurons and cardiac myocytes. J Neurosci, 1997, 17 (24) :9573-9582.

二级参考文献5

  • 1Teraoka K,Hirano M,Yamaguchi K,et al.Progressive cardiac dysfunction in adriamycin-induced cardio-myopathy rats[J].European Journal of Heart Failure,2000,2:373-378.
  • 2Minoru H,Tsutomu R,John R.Animal Models of Heart Failure[J].Trends Cardiovasc Med,1997,7:161-167.
  • 3Nohl H.Identification of the site of adriamycin activation in the heart cell[J].Biochem Pharmacol,1983,37:2633-2635.
  • 4Kawasaki N,Lee JD,Shimizu H,et al.Cardiac energy metabolism at several stages of adriamycin induced heart failure in rats[J].International Journal of Cardiology,1996,55:217-225.
  • 5Papadopoulou LC,Theophilidis G,Thomopoulos GN,et al.Structural and Functional Impairment of Mitochondria in Adriamycin Induced Cardiomyopathy in Mice:Suppression of Cytochrome c Oxidase Ⅱ Gene Expression[J].Biochemical Pharmacology,1999,57:481-489.

共引文献17

同被引文献39

  • 1曲秀芬,喜杨,于彦伟,王馥,李晶洁,黄永麟.心肌梗死后神经生长因子的动态表达及其与交感神经重构的关系[J].中华心血管病杂志,2004,32(12):1135-1138. 被引量：12
  • 2李书国,毛小波,郭张强,张峰,曾秋棠.α_1受体阻断剂对慢性心力衰竭大鼠心肌神经生长因子表达的影响[J].中国现代医学杂志,2007,17(17):2110-2113. 被引量：2
  • 3Zhou M, Wang H, Zhu J, et al. Cause-specific mortality for 240 causes in China during 1990 - 2013 : a systematic sub- national analysis for the Global Burden of Disease Study 2013 [ J]. Lancet,2016,387 ( 10 015) :251 - 272.
  • 4胡嘉禄,颜彦,侯月梅.干预交感神经治疗慢性心力衰竭研究[J].中华临床医师杂志:电子版,2013,7(24):11739-11741.
  • 5Qin F, Vulapalli RS, Stevens SY, et al. Loss of cardiac sym- pathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF [ J ]. Am J Physiol Heart Circ Physiol, 2002,282 ( 1 ) : H363 - H371.
  • 6Kimura K, Kanazawa H, Ieda M, et al. Norepinephrine-in- duced nerve growth factor depletion causes cardiac sympa- thetic denervation in severe heart failure [ J ]. Auton Neuros- ci,2010,156(1 -2) :27 -35.
  • 7Sano H, Kasama S, Fujimoto S, et al. Effects of statin therapy on cardiac sympathetic nerve activity and left ventricular re- modeling in patients with chronic heart failure:a propensity score-matched analysis [ J]. Medicine(Baltimore) ,2014,93 (27) :e214.
  • 8Wang HJ, Wang W, Cornish KG, et al. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and im- proves cardiovascular dysfunction in rats with heart failure [ J ]. Hypertension, 2014,64 ( 4 ) :745 - 755.
  • 9Ma L, Cui B, Shao Y, et al. Electroacupuncture improves cardiac function and remodeling by inhibition of sympatho- excitation in chronic heart failure rats [ J ]. Am J Physiol Heart Cire Physiol,2014,306(10) :H1 464 - H1 471.
  • 10D'Elia E, Pascale A, Marchesi N, et al. Novel approaches to the post-myocardial infarction/heart failure neural remode- ling [ J ]. Heart Fail Rev, 2014,19 ( 5 ) : 611 - 669.

引证文献2

二级引证文献10

中国医师杂志
2009年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部