摘要
目的评价99mTc-DTPA眼眶显像在甲状腺相关眼病(TAO)患者眼部炎性反应活动度中的临床应用价值。方法将26例TAO患者依据临床活动度评分(CAS)标准分为活动组16例、非活动组10例。另选14例正常志愿者作为对照组。静脉注射显像剂99mTc-DTPA30min后行眼眶平面及断层显像,采用勾画感兴趣区技术计算99mTc-DTPA眼眶与枕部摄取比值(UR)。结果活动组TAO患者眼眶UR均高于非活动组和正常对照组(均P<0.001);而非活动组TAO患者与正常人的眼眶UR比较,差异无统计学意义(P>0.05)。所有TAO患者的UR与其CAS呈线性正相关(rall=0.859,P<0.001)。结论99mTc-DTPA眼眶显像可帮助判断TAO炎性反应活动度,是一种很有发展前途的评价甲状腺相关性眼病眶周炎性活动的方法。
Objective To evaluate the value of ^99mTc-DTPA orbital SPECT/CT in thyroid associated ophthalmopathy（TAO）. Methods Acording to the clinical activitY score（CAS） ,26 patients were divided into two groups：active group（ AG, n = 16）and inactive group （IAG, n = 10）. Fourteen volunteers were included as controls. Scintigraphic images were obtained after intravenous injection of ^99mTc-DTPA for 0.5 h. The images were analyzed by a technique for specifying region of interest. The mean uptake ratio of the bilateral orbits was calculated. Results The mean orbit uptake ratio was higher significantly in AG group than in IAG group and control group（P 〈0.001 ）, but there was no statistics difference between IAG group and control group（ P 〉 0.05 ）. There was a linear positive correlation between the ratio and CAS in TAO patients. Conclusion ^99mTc-DTPA orbital SPECT/CT could be helpful for judging the active degree of TAO. ^99mTc-DTPA orbital SPECT is a promising method for estimating disease activity in the orbits of patients with TAO.
出处
《山西医科大学学报》
CAS
2009年第6期563-566,共4页
Journal of Shanxi Medical University
