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A novel synthesis of 5-aryl-3-cyano-2-pyridones by using vinamidinium salts

A novel synthesis of 5-aryl-3-cyano-2-pyridones by using vinamidinium salts
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摘要 A variety of vinamidinium salts were condensated with cyanoacetamide in refluxing methanol that contained sodium methoxide to produce 5-aryl-3-cyano-2-pyridones in good yield. Simple experimental conditions were used to prepare ten different 5-aryl-3- cyano-2-pyridones, four of which are new compounds.C 2009 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. A variety of vinamidinium salts were condensated with cyanoacetamide in refluxing methanol that contained sodium methoxide to produce 5-aryl-3-cyano-2-pyridones in good yield. Simple experimental conditions were used to prepare ten different 5-aryl-3- cyano-2-pyridones, four of which are new compounds.C 2009 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
作者 Xue Hui Zhang Wu Zhong Xing Zhou Li Song Li
机构地区 Beijing Institute of Pharmacology and Toxicology
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第7期771-774,共4页 中国化学快报（英文版）
基金 supported by the National Basic Research Program of China(No.2004CB518908) the National High Technology Research and Development Program of China(No.2006AA020601).
关键词 5-Aryl-3-cyano-2-pyridones Vinamidinium salts CYCLIZATION 5-Aryl-3-cyano-2-pyridones Vinamidinium salts Cyclization
分类号 O623.626 [理学—有机化学] TQ613.24 [化学工程—精细化工]
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  • 1I V. Gomez-Parra, M.C. Gomez, E Sanchez, V. Stefani, Arch. Pharm. (Weinheim) 325 (1992) 483.
  • 2M. Julia, H. Pinhas, J. Igolen, Bull. Soc. Chim. Ft. 7 (1966) 2387.
  • 3D. Lloyd, H. McNab, Angew. Chem. Int. Ed. Engl. 15 (1976) 459.
  • 4J.T. Gupton, D.A. Krolikowski, R.H. Yu, S.W. Riesinger, J.AI Sikorski, J. Org. Chem. 55 (1990) 4735.
  • 5R.T. Clemens, S.Q. Smith, Tetrahedron Lett. 46 (2005) 1319.
  • 6X.H. Zhang, H. Yu, Z.B. Zheng, S. Li, Junshi Yixue Kexueyuan Yuankan (Bull. Acad. Mil. Sci.) 30 (3) (2006) 240.
  • 7Z. Arnold, Collect. Czech. Chem. Commun. 26 (1961) 3051.
  • 8Generalprocedure: To a dry 50-mL, two-necked flask equipped with a reflux condenser and drying tube, was added 20 mL absolute methanol and sodium(46 rag, 2 mmol). The mixture was stirred for 5 rain. To the solution, cyanoacetarnide (84 nag, 1 mmol) and vinamidinium salt (1 mmol) were introduced. The mixture was refluxed for several hours during which time a solid separated, cooled to room temperature. The mixture was added 15 mL water, acidified with 1 mol/L HC1. The solid crude product was filtered, washed with water and hexane, and then recrystilized in methanol to obtain purified product.
  • 9G.Y. Lesher, C.J.J. Opalka, D.E Page, Eur. Pat. Appl. 61774 (1982);.
  • 10G.Y. Lesher, CJ.J. Opalka, D.E Page, Chem. Abstr. 98 (1983) 71948.
Chinese Chemical Letters
2009年 第7期

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