摘要
目的:探讨大黄和丹参联合应用对重症急性胰腺炎(SAP)的治疗价值.方法:分析我院收治的SAP患者98例,根据用药分为对照组(A组,21例)、丹参治疗组(B组,25例)和大黄加丹参治疗组(C组,52例).A组采用常规治疗,B组和C组在对照组治疗的基础上分别加用丹参和大黄加丹参治疗.分析3组间肠鸣音恢复、器官损害数、感染部位数、假性胰腺囊肿数和住院时间及死亡率.结果:与A组比较,C组肠鸣音恢复明显快(t1)、器官损害数(t2)、感染部位数(t3)、假性胰腺囊肿数(χ2)和住院时间显著减少(t4)(t1=2.34,t2=2.17,t3=3.04,χ2=13.76,t4=3.65,均P<0.05),C组的死亡率也降低,但差异不显著;B组除器官损害数显著降低外(t=3.45P<0.05),肠鸣音恢复、感染部位数、假性胰腺囊肿数和住院时间无明显差别;C组与B组比较,C组肠鸣音恢复、感染部位数、死亡率、假性胰腺囊肿数和住院天数均优于B组,但其中仅有肠鸣音恢复最为显著(t=2.73,P<0.05).结论:在常规治疗基础上,联合应用大黄和丹参治疗SAP有协同作用,能明显改善临床效果.
AIM： To investigate the therapeutic effects of Rhubarb and Salvia miltiorrhiza on severe acute pancreatitis （SAP） METHODS： Ninety-eight patients with SAP were divided into three groups： control group （group A, n =21）, Salvia miltiorrhiza treatment group （group B, n = 25） and Rhubarb ＆ Salvia miltiorrhiza treatment group （group C, n = 52）. All the patients in the 3 groups received the same routine therapy while group B and group C received additional treatment of salvia miltiorrhiza and the combined management of Rhubarb ＆ Salvia miltiorrhiza respectively. RESULTS： Compared with group A, group C had faster recovery of intestinal gurgling sound （t1） and less important organ injury （t2）, fewer infective positions （t3）, pancreatic pseudocysts （;（2） and significantly decreased hospital days （t4） （t1 = 2.34, t2 = 2.17, 6=3.04, x2= 13.76, t4 = 3.65, all P 〈 0.05） and lower mortality. Compared with group A, group B had a significant reduce in organ injury （t = 3.45, P 〈 0.05）, while had no dif-ference in recovery of intestinal gurgling sound, and in the number of infective positions, pancreatic pseudocysts and hospital days. Compared with group B, group C had better recovery of intestinal gurgling sound with significant difference （t = 2.73, P 〈 0.05）. CONCLUSION： On the basis of routine treatment, combined management of Rhubarb and Salvia miltiorrhiza for treating SAP possesses a significant synergistic action and therapeutic effect.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第14期1481-1483,共3页
World Chinese Journal of Digestology
关键词
重症急性胰腺炎
并发症
大黄
丹参
Severe acute pancreatitis
Complication
Rhubarb
Salvia miltiorrhiza
