摘要
目的评测腰椎前凸程度和(或)椎体序列不规则性对于腰椎骨折危险性是否具有独立的预测价值。方法选择72例绝经后妇女,平均随访7.5年,其中36例随访过程中未发生椎体骨折(对照组),另36例至少发生一个腰椎骨折(研究组)。此两组基础数据在年龄、BMI、L1～L4BMD(DEXA)、吸烟史以及体育锻炼方面均匹配。应用图像分析软件对腰椎侧位X线平片进行分析,评价腰椎前凸程度和椎体序列不规则性。结果基础数据显示,研究组的椎体序列不规则性明显高于对照组(1.5×10-3vs2.0×10-3,P=0.002);而两组间的腰椎前凸程度差异无统计学意义。随访资料显示研究组椎体序列不规则性明显增加(2.8×10-3,P<0.001);而对照组无明显变化(1.4×10-3,P=0.58)。结论计算机测定椎体序列不规则性对椎体骨折有预测价值,而不依赖于BMD,可作为对老年妇女骨质疏松椎体骨折危险性评价的有价值的补充。
Objective To investigate whether the degree of lordosis and/or irregularities in vertebral alignment are the independent contributors to the risk of fragility fractures in the lumbar spine. Methods Seventy-two postmenopausal women were included, 36 of them maintained skeletal integrity （control group） and 36 sustained at least one fracture （research group） in the lumbar spine over a 7.5-year follow up. The baseline of age, BMI, spine BMD L1-L4 （DEXA）, smoking habits and physical activity matched in two groups. The degree of lordosis as well as irregularity of vertebral alignment was assessed on digital lateral X-ray films using image analyzer software. Results At baseline, the irregularity in research group was significantly higher than that in control group （1.5 × 10 ^-3 vs 2.0 × 10^-3 , P=0. 002） ; there was no statistical difference of lordosis between the two groups. The irregularity of vertebral alignment increased in research group （2.8 × 10^- 3, p〈 0. 001）, while maintain unchanged in control group （1.4 × 10 ^-3, P=0.58）. Conclusion This computer-based measurement of vertebral alignment irregularity has predictive value on vertebral fracture, and can serve as a useful supplement to fracture risk assessment in elderly women.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第6期1081-1084,共4页
Chinese Journal of Medical Imaging Technology
关键词
骨折
椎体序列
脊柱前凸
腰椎
Fractures
Vertebral alignment
Lordosis
Lumbar spine
