摘要
目的观察三维适形放射治疗（3D-CRT）老年非小细胞肺癌患者的疗效和副反应。方法2004年5月~2008年10月应用3D-CRT技术治疗70岁以上非小细胞肺癌患者80例。以北京大恒Star-2000三维放疗计划系统制订放疗计划,处方剂量为40~80 Gy（中位剂量60 Gy）。其中采用低分割照射者35例,单次分割剂量5~8 Gy,隔日照射,共8~12次照射;常规分割者45例,共30~40次照射。观察所有患者的肿瘤反应率,1、2年的生存率及治疗毒副作用。结果69例患者治疗后临床症状获得改善,11例无变化。肿瘤获得完全缓解19例,部分缓解50例,肿瘤总反应率86.25%。全组生存时间为2~53个月,中位生存时间8个月,1年生存率66.25%,2年生存率30%。无严重并发症。结论对于老年非小细胞肺癌患者,3D-CRT技术是一种安全有效的治疗手段,能够改善生存质量,提高生存率。
Objective To evaluate the therapeutic effects and adverse effects of three-di conformal radiotherapy （3D-CRT） for elderly patients with non-small cell lung cancer （NSC MethodsMay 2004 to October 2008,80 patients over 70 years old with NSCLC were treated by 3D- jing Star-2000 treatment plan system was used as drafting radiotherapy plan, the prescription dose 80 Gy （mediun,60 Gy）. Thirly-fave patients received hypofractionated radiation every two days mensional LC ）. CRT. Bei was 40 - in 8 -12 fractions at a dose of 5 -8 Gy per fraction; Forty-four patients accepted conventional fractionated radiation with 30 - 40 fractions during 6 to 7 weeks, tumor response rate was observed, 1-year and 2-year survival rate were investigated, adverse effects of the treatment were also recorded. Results Clinical symptoms were improved in 66 cases, while no changes were observed in 11 cases. 16 patients showed complete response （CR） ,50 cases partial response （PR）, with the overall tumor response rate of 86.25% （69/80）. In this group, 1-year and 2-year survival rate was 66.25% and 30% with median survival time of 8 months （range, 2 - 53months）. No patients suffered from serious adverse effects. Conclusion 3D-CRT is an effective and safe treatment for elderly patients with NSCLC,which could raise the survival rate and improve the quality of life.
出处
《河南科技大学学报（医学版）》
2009年第2期93-95,共3页
Journal of Henan University of Science & Technology:Medical Science
关键词
非小细胞肺癌
放射疗法
适形
老年人
carcinoma
non-smallcell lung
radiotherapy
conformal
aged
